2295813-15-7
Chemical Structure
DOPE-Mal
- CAS No.: 2295813-15-7
- Formula:C48H83N2O11P
- Molecular Weight:895.15
InChIKey: LCNRIZXWHOCCGU-OYJIOEIKSA-N
SMILES: C(CC(NCCOP(OC[C@@H](COC(CCCCCCC/C=C\CCCCCCCC)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)(=O)O)=O)N1C(=O)C=CC1=O
Biological Activity: DOPE-Mal is an N-maleimide-derived phosphatidylethanolamine. DOPE-Mal does not interfere with fatty acyl chains or alter lipid bilayer permeability; it increases lipid bilayer order, reduces fluidity, induces conformational changes in phospholipid polar heads and enhances their hydration. DOPE-Mal can be used as a component to prepare maleimide-displaying liposomes, enabling peptide conjugation via maleimide-thiol coupling. DOPE-Mal can be used to prepare Liposomes for delivering Doxorubicin (HY-15142A) to hepatocytes. DOPE-Mal is applicable to research related to hepatocellular carcinoma and lung cancer[1][2][3].
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DOPE-Mal | 99.77% | DOPE-Mal is an N-maleimide-derived phosphatidylethanolamine. DOPE-Mal does not interfere with fatty acyl chains or alter lipid bilayer permeability; it increases lipid bilayer order, reduces fluidity, induces conformational changes in phospholipid polar heads and enhances their hydration. DOPE-Mal can be used as a component to prepare maleimide-displaying liposomes, enabling peptide conjugation via maleimide-thiol coupling. DOPE-Mal can be used to prepare Liposomes for delivering Doxorubicin (HY-15142A) to hepatocytes. DOPE-Mal is applicable to research related to hepatocellular carcinoma and lung cancer. | ||||||||||||||||||||
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- [1]. Ballesteros U, et al. Effects of a -Maleimide-derivatized Phosphatidylethanolamine on the Architecture and Properties of Lipid Bilayers. International journal of molecular sciences. 2023 Nov 21;24(23):16570. [Content Brief]
- [2]. Liu Q, et al. A hepatitis B virus-derived human hepatic cell-specific heparin-binding peptide: identification and application to a drug delivery system. Biomaterials science. 2018 Dec 18;7(1):322-335. [Content Brief]
- [3]. Zhong Q, et al. Conditional fusogenic lipid nanocarriers for cytosolic delivery of macromolecular therapeutics[J]. bioRxiv, 2024: 2024.12. 27.630514.
Keywords
