2757682-01-0
Chemical Structure
NRERf
- CAS No.: 2757682-01-0
- Formula:C53H69F5N4O15
- Molecular Weight:1097.12
InChIKey: IZBVCUUQLJDOMU-UHFFFAOYSA-N
SMILES: CCN(C1=CC=C2N=C3C(OC2=C1)=CC(C4=C3C=CC=C4)=O)CCCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(C5=C(C(F)=C(C(F)=C5F)F)F)=O)=O
Biological Activity: NRERf is an endoplasmic reticulum (ER)-targeted solvatochromic fluorescent probe based on Nile Red (HY-D0718). It possesses ER-targeting capability and can sense changes in local polarity and lipid order of biological membranes. NRERf undergoes excited-state charge transfer, with its emission color changing according to local polarity: the tightly packed, low-polarity liquid-ordered phase (Lo) induces a blue-shifted emission, while the high-polarity liquid-disordered phase (Ld) induces a red-shifted emission. The emission wavelength of NRERf varies with the environment. NRERf can be used to detect changes in lipid order and polarity induced in the ER by cholesterol extraction/enrichment, oxidative stress, and hyperosmotic shock[1].
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NRERf | NRERf is an endoplasmic reticulum (ER)-targeted solvatochromic fluorescent probe based on Nile Red (HY-D0718). It possesses ER-targeting capability and can sense changes in local polarity and lipid order of biological membranes. NRERf undergoes excited-state charge transfer, with its emission color changing according to local polarity: the tightly packed, low-polarity liquid-ordered phase (Lo) induces a blue-shifted emission, while the high-polarity liquid-disordered phase (Ld) induces a red-shifted emission. The emission wavelength of NRERf varies with the environment. NRERf can be used to detect changes in lipid order and polarity induced in the ER by cholesterol extraction/enrichment, oxidative stress, and hyperosmotic shock. | |||||||||||||||||||||
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Keywords
