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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
mRNA maturation
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "mRNA maturation" in MCE Product Catalog:
Cat. No.: HY-W416291
CAS No.: 26763-19-9
Synonyms: Poly(A)
Polyadenylic acid potassium (Poly(A)) is a polyribonucleotide. Polyadenylic acid potassium constitutes the 3'-poly(A) tail of eukaryotic mRNAs, governing mRNA maturation, stability, and translation initiation. Polyadenylic acid potassium serves as a target for studying nucleic acid structure-function relationships, with small molecules binding its tail influencing mRNA function and protein production. Polyadenylic acid (potassium) can be used for the research of cancer .
Cat. No.: HY-W587733
CAS No.: 1662-06-2
Synonyms: 17,20β-P; 17,20β-DHP
Research Areas:
17α,20β-Dihydroxy-4-pregnen-3-one (17,20β-P; 17,20β-DHP) acts as the maturation-inducing hormone (MIH) in salmonid fish and rainbow trout. 17α,20β-Dihydroxy-4-pregnen-3-one binds to oocyte-specific plasma membrane receptors and pertussis toxin-sensitive inhibitory G proteins in fish, inhibits Adenylate Cyclase and reduces intracellular cAMP via the membrane receptor-G protein coupling pathway, thereby initiating downstream signal transduction. 17α,20β-Dihydroxy-4-pregnen-3-one induces de novo synthesis of cyclin B, mediates the translation of cyclin B mRNA and the phosphorylation of cdc2, and promotes the production of maturation-promoting factor (MPF). 17α,20β-Dihydroxy-4-pregnen-3-one drives meiotic maturation of fish oocytes. 17α,20β-Dihydroxy-4-pregnen-3-one is applicable for development-related research .
Cat. No.: HY-153238
CAS No.: 2152662-92-3
AN15368 is an orally active trypanocidal agent and a prodrug of AN14667. AN15368 selectively targets CPSF3-mediated mRNA maturation in intracellular amastigotes of Trypanosoma cruzi, reducing the mRNA levels of the parasite. As a prodrug, AN15368 can be cleaved into its active carboxylate form by CBP of Trypanosoma cruzi. AN15368 completely clears long-term naturally acquired Trypanosoma cruzi infections in non-human primates. AN15368 can be used in the research of Chagas disease .
Cat. No.: HY-112905
CAS No.: 2152662-85-4
AN11736 is a CPSF3 inhibitor. AN11736 exerts a potent anti-trypsin effect by specifically inhibiting the activity of the trypanosome CPSF3 endonuclease, disrupting the mRNA maturation process. AN11736 exhibits IC50s against T. congolense and T. vivax of 0.14 and 1.3 nM, respectively. AN11736 exhibits strong anti-trypsin activity in mouse and cattle models .
Cat. No.: HY-174716
Target:
Research Areas:
Human EREG mRNA encodes the human epiregulin (EREG) protein, a member of the epidermal growth factor family. EREG may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation.
Cat. No.: HY-174742
Target:
Research Areas:
Human CCR7 mRNA encodes the human C-C motif chemokine receptor 7 (CCR7) protein, a member of the G protein-coupled receptor family. CCR7 has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation.
Cat. No.: HY-174607
Target:
Research Areas:
Human IL33 mRNA encodes the human interleukin 33 (IL33) protein, a cytokine that binds to the IL1RL1/ST2 receptor. IL33 is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells.
Cat. No.: HY-174639
Target:
Research Areas:
Human IL13 mRNA encodes the human interleukin 13 (IL13) protein, an immunoregulatory cytokine produced primarily by activated Th2 cells. IL13 is involved in several stages of B-cell maturation and differentiation and is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils.
Cat. No.: HY-174592
Human kruppel like factor 4 (KLF4) mRNA encodes a protein that belongs to the Kruppel family of transcription factors. KLF4 protein is thought to regulate the expression of key transcription factors during embryonic development and play an important role in maintaining embryonic stem cells, and in preventing their differentiation. In addition it is also required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface.
Cat. No.: HY-174600
Target:
Research Areas:
Human IL6 mRNA encodes the human interleukin 6 (IL6) protein, a cytokine that functions in inflammation and the maturation of B cells. IL6 has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
Cat. No.: HY-174590
Human Lin-28 homolog A (LIN28A) mRNA encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. LIN28A functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development.
Cat. No.: HY-174602
Target:
Research Areas:
Human IL5 mRNA encodes the human interleukin 5 (IL5) protein, a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL5 plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases.
Cat. No.: HY-185002
BCMA CAR mRNA can express the CAR protein targeting human BCMA. BCMA CAR mRNA can trigger the transient expression of CAR, enabling T cells to be targeted without the need for permanent genetic modification. BCMA is a member of the tumor necrosis factor receptor superfamily 17 (TNFRSF17), also known as B-cell maturation antigen (CD269), which promotes B-cell survival and plays a role in regulating humoral immunity. BCMA is highly expressed in multiple myeloma and is a biomarker for the diagnosis of multiple myeloma.
Cat. No.: HY-174504
Target:
Research Areas:
Human ZIC1 mRNA encodes the human Zic family member 1 (ZIC1) protein, a member of the ZIC family of C2H2-type zinc finger proteins. ZIC1 plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum.
Cat. No.: HY-16362
CAS No.: 195883-09-1
Synonyms: PG 490-88Na
Research Areas:
Omtriptolide sodium (PG490-88Na) is a derivative of Triptolide (HY-32735). Omtriptolide sodium exhibits significant immunosuppressive, anti-fibrotic and anti-inflammatory properties. The mechanism of action of Omtriptolide sodium is diverse, including inhibiting T cell activation and proliferation, inducing T cell apoptosis (apoptosis), blocking fibroblast maturation/proliferation, inhibiting TGF-β mRNA expression, and suppressing pro-inflammatory cytokines (such as IL-2, IFN-γ, TNF-α) by blocking transcription factors such as NF-κB. Omtriptolide sodium can be used for research on obstructive airway diseases, pulmonary fibrosis and graft-versus-host disease .
Cat. No.: HY-P75465
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MRTO4; MRT4, mRNA Turnover 4, Homolog (S. Cerevisiae); Prev. C1orf33; Chromosome 1 Open Reading Frame 33; MRT4; MRTO4 Ribosome maturation Factor; DJ657E11.4; 60S Acidic Ribosomal Protein PO; mRNA Turnover Protein 4 Homolog; MRT4, mRNA Turnover 4, Homolog
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
