2152662-92-3
Chemical Structure
AN15368
- CAS No.: 2152662-92-3
- Formula:C20H28BNO6
- Molecular Weight:389.25
IUPAC Name: (tetrahydro-2H-pyran-4-yl)methyl (1-hydroxy-7-methyl-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbonyl)-L-valinate
InChIKey: MCKPYEQRZUCJKI-SFHVURJKSA-N
SMILES: OB1OCC2=C1C(C)=C(C=C2)C(N[C@@H](C(C)C)C(OCC3CCOCC3)=O)=O
Biological Activity: AN15368 is an orally active trypanocidal agent and a prodrug of AN14667. AN15368 selectively targets CPSF3-mediated mRNA maturation in intracellular amastigotes of Trypanosoma cruzi, reducing the mRNA levels of the parasite. As a prodrug, AN15368 can be cleaved into its active carboxylate form by CBP of Trypanosoma cruzi. AN15368 completely clears long-term naturally acquired Trypanosoma cruzi infections in non-human primates. AN15368 can be used in the research of Chagas disease[1].
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AN15368 | AN15368 is an orally active trypanocidal agent and a prodrug of AN14667. AN15368 selectively targets CPSF3-mediated mRNA maturation in intracellular amastigotes of Trypanosoma cruzi, reducing the mRNA levels of the parasite. As a prodrug, AN15368 can be cleaved into its active carboxylate form by CBP of Trypanosoma cruzi. AN15368 completely clears long-term naturally acquired Trypanosoma cruzi infections in non-human primates. AN15368 can be used in the research of Chagas disease. | |||||||||||||||||||||
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Keywords
