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mastoparan

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (2) Biochemical Assay Reagents (2) Endogenous Metabolite (2) mTOR (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (2) Metabolic Disease (2) Neurological Disease (1)

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Peptides

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Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1732

Transportan	Biochemical Assay Reagents	Cancer
Transportan is an amphipathic cell-penetrating peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine. Transportan interacts with galanin receptors and G-proteins, modulates GTPase activity, enters cells via direct translocation and endocytic pathways, accumulates in cytoplasmic, nuclear, and membranous structures, and delivers cargo including peptides, PNAs, proteins, siRNA, and liposomes ^[12].

HY-P0246

*Mastoparan*	Endogenous Metabolite	Metabolic Disease
Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells.

HY-P2705

Mastoparan X	Endogenous Metabolite	Others
Mastoparan X is a GTP-binding regulatory protein (G protein)-activating peptide, and a tetradecapeptide from wasp venom. Mastoparan X acts function by the direct activation of G protein that couple to phospholipase C to cause secretion from various kinds of cells .

HY-P3072

Mastoparan 17	mTOR	Metabolic Disease
Mastoparan 17 is a tetradecapeptide. Mastoparan 17 is an inactive analogue of Mastoparan (HY-P0246) .

HY-P0258

Mas7 mastoparan 7	Apoptosis	Cardiovascular Disease Neurological Disease
Mas7 (Mastoparan 7), a structural analogue of mastoparan, is an activator of heterotrimeric Gi proteins and its downstream effectors.

HY-P2576

Polistes mastoparan	Bacterial	Infection
Polistes mastoparan is an antimicrobial peptide. Polistes mastoparan increases S. aureus cell K ⁺ efflux and inhibits cell viability with EC₅₀ of 5 μM .

HY-P5602

Mastoparan B	Bacterial	Infection
Mastoparan B is an antimicrobial peptide derived from hornet Vespa. Mastoparan B can cause the shape of red blood cells to change from normal disk-like to serrated .

HY-P11601

MAF-10L	Biochemical Assay Reagents	Cancer
MAF-10L is a membrane-disrupting agent, a cationic amphipathic Mastoparan AF derivative with enhanced α-helicity. MAF-10L preferentially interacts with DOPS lipids in cancer cell membranes, disrupting cancer cell membranes to trigger membrane leakage. MAF-10L can be used for the research of cancer .

Cat. No.	Product Name	Target	Research Area

HY-P1732

Transportan	Biochemical Assay Reagents	Cancer
Transportan is an amphipathic cell-penetrating peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine. Transportan interacts with galanin receptors and G-proteins, modulates GTPase activity, enters cells via direct translocation and endocytic pathways, accumulates in cytoplasmic, nuclear, and membranous structures, and delivers cargo including peptides, PNAs, proteins, siRNA, and liposomes ^[12].

HY-P0246

*Mastoparan*	Endogenous Metabolite	Metabolic Disease
Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells.

HY-P2705

Mastoparan X	Endogenous Metabolite	Others
Mastoparan X is a GTP-binding regulatory protein (G protein)-activating peptide, and a tetradecapeptide from wasp venom. Mastoparan X acts function by the direct activation of G protein that couple to phospholipase C to cause secretion from various kinds of cells .

HY-P3072

Mastoparan 17	mTOR	Metabolic Disease
Mastoparan 17 is a tetradecapeptide. Mastoparan 17 is an inactive analogue of Mastoparan (HY-P0246) .

HY-P0258

Mas7 mastoparan 7	Apoptosis	Cardiovascular Disease Neurological Disease
Mas7 (Mastoparan 7), a structural analogue of mastoparan, is an activator of heterotrimeric Gi proteins and its downstream effectors.

HY-P11128

Mastoparan-V1	Peptides	Others
Mastoparan-V1 is a peptide belonging to the Mastoparan family. Mastoparan-V1 exhibits modest mast cell degranulation activity, with EC₅₀ of 130.24 μM in RBL-2H3 cells. Mastoparan-V1 can be used for the study of allergic reactions induced by wasp stings .

HY-P2576

Polistes mastoparan	Bacterial	Infection
Polistes mastoparan is an antimicrobial peptide. Polistes mastoparan increases S. aureus cell K ⁺ efflux and inhibits cell viability with EC₅₀ of 5 μM .

HY-P3284

Mastoparan M tetraacetate	Peptides	Cancer
Mastoparan M tetraacetate is a tetrapeptide amide isolated from the Chinese giant hornet (Vespa mandarinia). The amino acid sequence of Mastoparan M tetraacetate shares some structural homology with Mastoparan X, a wasp venom isolated from the Chinese giant hornet as well .

HY-P5602

Mastoparan B	Bacterial	Infection
Mastoparan B is an antimicrobial peptide derived from hornet Vespa. Mastoparan B can cause the shape of red blood cells to change from normal disk-like to serrated .

HY-P11601

MAF-10L	Biochemical Assay Reagents	Cancer
MAF-10L is a membrane-disrupting agent, a cationic amphipathic Mastoparan AF derivative with enhanced α-helicity. MAF-10L preferentially interacts with DOPS lipids in cancer cell membranes, disrupting cancer cell membranes to trigger membrane leakage. MAF-10L can be used for the research of cancer .

*Mastoparan*	Natural Products Animals Classification of Application Fields Metabolic Disease Disease Research Fields Source Classification	Endogenous Metabolite
Mastoparan, a tetradecapeptide which is a component of wasp venom, stimulates release of prolactin from cultured rat anterior pituitary cells.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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mastoparan

Inhibitors & Agonists

Peptides

NaturalProducts

Natural
Products