MAF-10L

MAF-10L (50 µM) shows the highest α-helical content among tested derivatives, with 48.7% helicity in PBS and 99.7% helicity in 10% SDS^[1].
MAF-10L (50 µM) has the highest self-association propensity in the MAF series^[1].
MAF-10L (0.39-200 µM; 6 h) exhibits potent anticancer activity against 4T1, B16F10, CT26, A549, and Hep3b cells with IC₅₀ values ranging from 2.4 to 9.2 µM^[1].
MAF-10L (4-128 µM; 20 min) exhibits elevated hemolytic activity on RBCs, with higher percentages at increased concentrations^[1].
MAF-10L (5-10 µM; 1 h) damages the plasma membrane of A549 cells, leading to increased PI uptake^[1].
MAF-10L (50 ns) maintains a fully α-helical structure during 50 ns MD simulation in water^[1].
MAF-10L (50 ns) translocates across the cancer cell membrane model with a low energy barrier and minimal lipid disruption, supported by its α-helical structure^[1].
MAF-10L (2 µM; 6 h) triggers hallmarks of immunogenic cell death in cancer cells, including elevated calreticulin expression and ATP release^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.