18 Results for "

oxidized phospholipids

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "oxidized phospholipids" in MCE Product Catalog:

  • Targets Recommended:
5
5 Cited Publications
Cat. No.: HY-125623
CAS No.: 1392820-50-6
Purity:  98.14%
MitoPerOx is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state), and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction)[1][2].
loading...
    loading...
Cat. No.: HY-101541
CAS No.: 2566-90-7
Purity:  ≥95.0%
Synonyms: Methyl docosahexaenoate; all cis-DHA methyl ester
Target:  

Drug Intermediate

Research Areas:  

Neurological Disease

Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
loading...
    loading...
Cat. No.: HY-DY1073
CAS No.: 1392820-50-6
MitoPerOx (solution) is a mitochondrial-targeted, lipid peroxidation-indicating fluorescent probe with BODIPY581/591 fluorophores. The triphenylphosphine cation (TPP+) of MitoPerOx can be selectively enriched in mitochondria (depending on membrane potential) and can be used to detect lipid peroxidation in the inner mitochondrial membrane. Under the action of lipid peroxides, the BODIPY581/591 fluorophores of MitoPerOx shift their emission wavelength from 590 nm (reduced state) to 520 nm (oxidized state) , and ratiometric detection can be performed at an excitation wavelength of 488 nm. MitoPerOx can specifically monitor the peroxidation of mitochondrial phospholipids (especially cardiolipin) and is used in the study of oxidative stress-related diseases (such as aging, neurodegenerative diseases, and mitochondrial dysfunction) .
Solvent and concentration: DMSO: 2 mM
loading...
    loading...
Cat. No.: HY-W040255
CAS No.: 89947-79-5
Synonyms: PGPC
1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is an oxidized phospholipid. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine reduces the viability of HUVECs, increases the levels of ferrous ions and lipid peroxidation, promotes the production of superoxide anions, and decreases the levels of glutathione and GPX4 in cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine upregulates the mRNA and protein levels of FABP3 in HUVECs, impairs mitochondrial membrane potential, and induces ferroptosis-related changes as well as mitochondrial dysfunction and damage. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine activates caspase-11 and promotes the continuous release of IL-1β from macrophages and dendritic cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine inhibits the proliferation of aortic smooth muscle cells and induces apoptosis in these cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is applicable to relevant research on atherosclerosis .
loading...
    loading...
Cat. No.: HY-130576
CAS No.: 121324-31-0
Target:  

Apoptosis

Research Areas:  

Cardiovascular Disease

POVPC is an oxidized phospholipid can be found in in oxidatively modified low density lipoprotein (oxLDL). POVPC inhibits VSMC growth in high serum condition. POVPC induces apoptosis in low serum condition .
loading...
    loading...
Cat. No.: HY-165029
CAS No.: 17708-90-6
Synonyms: PLPC
Target:  

Liposome

1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC (PLPC) is a phosphatidylcholine phospholipid. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC and oxidized derivatives serve as models for investigating lipid peroxidation, membrane structure, and phospholipase A2 activity. 1-Palmitoyl-2-linoleoyl-sn-glycero-3-PC can be applied in research on atherosclerosis, oxidative stress, and the properties of lipid bilayers .
loading...
    loading...
Cat. No.: HY-141636
CAS No.: 35418-58-7
Purity:  ≥99.0%
Synonyms: 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine; PAPC; PC(16:0/20:4)
1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells.
loading...
    loading...
Cat. No.: HY-101541S
CAS No.: 2687960-96-7
Synonyms: Methyl docosahexaenoate-d5; all cis-DHA methyl ester-d5
Docosahexaenoic acid-d5 methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed .
loading...
    loading...
Cat. No.: HY-154857
CAS No.: 89947-80-8
Research Areas:  

Cancer

1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures .
loading...
    loading...
Cat. No.: HY-101132A
CAS No.: 873842-97-8
Research Areas:  

Inflammation/Immunology

(Rac)-VB-201 is the racemate of VB-201, an oxidized phospholipid small molecule that inhibits CD14- and toll-like receptor 2-dependent innate cell activation and suppresses atherosclerosis .
loading...
    loading...
Cat. No.: HY-101541R
CAS No.: 2566-90-7
Synonyms: Methyl docosahexaenoate (Standard); all cis-DHA methyl ester (Standard)
Docosahexaenoic acid methyl ester (Standard) is the analytical standard of Docosahexaenoic acid methyl ester. This product is intended for research and analytical applications. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
loading...
    loading...
Cat. No.: HY-126551
CAS No.: 474944-25-7
Butenoyl-PAF is a phospholipid analog of platelet activating factor (PAF-like) that is generated in oxidized low-density lipoprotein (DLDR). Butenoyl-PAF can activate cells that express human PAF receptors, such as neutrophils, monocytes, and platelets, and it stimulates an increase in intracellular calcium ion concentration .
loading...
    loading...
Cat. No.: HY-101132
CAS No.: 630112-41-3
Target:  

Endogenous Metabolite

Research Areas:  

Inflammation/Immunology

VB-201 is an oxidized phospholipid small molecule with anti-inflammatory activity. VB-201 inhibits CD14- and Toll-like receptor 2-dependent innate cell activation. VB-201 limits the progression of atherosclerosis and can be used to study atherosclerosis .
loading...
    loading...
Cat. No.: HY-141636S
CAS No.: 1872379-11-7
Synonyms: 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d9-1; PAPC-d9-1; PC(16:0/20:4)-d9-1
1-PalMitoyl-2-arachidoyllecithin-d9-1 (1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d9-1) is deuterium labeled 1-PalMitoyl-2-arachidoyllecithin. 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells .
loading...
    loading...
Cat. No.: HY-168371
CAS No.: 161923-56-4
1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC (13-HODE-PC) is an oxidized phospholipid that contains Palmitic acid (HY-N0830) and 13(S)-HODE (HY-113884B) at the sn-1 and sn-2 positions, respectively. 1-Palmitoyl-2-13(S)-HODE-sn-glycero-3-PC has the ability to compete for the binding of 125I-NO2-LDL (5 g/mL) to CD36-transfected 293 cells, with the IC50 of > 200 μM .
loading...
    loading...
Cat. No.: HY-147076
CAS No.: 474943-21-0
Synonyms: 1,2-Diarachidonoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] sodium
20:4 PG (1,2-Diarachidonoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]) sodium is a glycerophospholipid that can be used as an oxidized phospholipid .
loading...
    loading...
Cat. No.: HY-175111
Target:  

Liposome

Research Areas:  

Others

1-Stearoyl-2-17(S)-HDoTE-sn-glycero-3-PC is a phospholipid that contains stearic acid (HY-B2219) and the oxidized adrenic acid metabolite 17(S)-HDoTE (HY-168774) at the sn-1 and sn-2 positions, respectively .
loading...
    loading...
Cat. No.: HY-175115
Target:  

Liposome

Research Areas:  

Others

1-Stearoyl-2-17(S)-HDoTE-sn-glycero-3-PE is a phospholipid. 1-Stearoyl-2-17(S)-HDoTE-sn-glycero-3-PE contains Stearic acid (HY-B2219) and the oxidized adrenic acid metabolite 17(S)-HDoTE (HY-168774) at the sn-1 and sn-2 positions, respectively.
loading...
    loading...
  • 1