89947-79-5
89947-79-5
Chemical Structure
1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine
Synonym(s): PGPC
- CAS No.: 89947-79-5
- Formula:C29H56NO10P
- Molecular Weight:609.73
IUPAC Name: (R)-2-((4-carboxybutanoyl)oxy)-3-(palmitoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: CDZVJFRXJAUXPP-AREMUKBSSA-N
SMILES: C[N+](C)(C)CCOP(OC[C@H](OC(CCCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)([O-])=O
Biological Activity: 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is an oxidized phospholipid. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine reduces the viability of HUVECs, increases the levels of ferrous ions and lipid peroxidation, promotes the production of superoxide anions, and decreases the levels of glutathione and GPX4 in cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine upregulates the mRNA and protein levels of FABP3 in HUVECs, impairs mitochondrial membrane potential, and induces ferroptosis-related changes as well as mitochondrial dysfunction and damage. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine activates caspase-11 and promotes the continuous release of IL-1β from macrophages and dendritic cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine inhibits the proliferation of aortic smooth muscle cells and induces apoptosis in these cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is applicable to relevant research on atherosclerosis[1][2][3][4].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine | 99.68% | 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is an oxidized phospholipid. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine reduces the viability of HUVECs, increases the levels of ferrous ions and lipid peroxidation, promotes the production of superoxide anions, and decreases the levels of glutathione and GPX4 in cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine upregulates the mRNA and protein levels of FABP3 in HUVECs, impairs mitochondrial membrane potential, and induces ferroptosis-related changes as well as mitochondrial dysfunction and damage. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine activates caspase-11 and promotes the continuous release of IL-1β from macrophages and dendritic cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine inhibits the proliferation of aortic smooth muscle cells and induces apoptosis in these cells. 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine is applicable to relevant research on atherosclerosis. | ||||||||||||||||||||
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KOdiA-PC | 95.45% | Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species that are cytotoxic and proatherogenic. Many of these species were recently isolated and purified from oxLDL and identified as phosphatidylcholine species containing fragmented oxidized short-chain fatty acid residues at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl)phosphatidylcholine or KOdiA-PC is one of the most potent CD36 ligands of the oxLDL species. KOdiA-PC confers CD36 scavenger receptor binding affinity to LDL at a frequency of only 2 to 3 KOdiA-PC molecules/LDL particle and may be one of the more important structural determinants of oxLDL. | ||||||||||||||||||||
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POVPC | 99% | POVPC is an oxidized phospholipid can be found in in oxidatively modified low density lipoprotein (oxLDL). POVPC inhibits VSMC growth in high serum condition. POVPC induces apoptosis in low serum condition. | ||||||||||||||||||||
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1,2-Didecanoyl PC | 99.74% | 1,2-Didecanoyl PC (1,2-Didecanoyl-sn-glycero-3-phosphocholine) is an orally effective medium-chain saturated phospholipid with well-defined P-gp inhibitory activity and membrane-modulating functions. As a functional excipient/absorption enhancer, 1,2-Didecanoyl PC is particularly suitable for oral formulations of P-gp substrates (e.g., Ritonavir (HY-90001)). | ||||||||||||||||||||
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PAz-PC | 99.9% | Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. PAz-PC (Azelaoyl PC) is one of the predominant oxLDL species and may be one of the important structural determinants of oxLDL. | ||||||||||||||||||||
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1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine | 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures. | |||||||||||||||||||||
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POBPC | POBPC is a oxidized lipid. | |||||||||||||||||||||
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14:0-14:0(COOH) PC | 14:0-14:0(COOH) PC is a lipid for supported monolayer. | |||||||||||||||||||||
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1-Palmitoyl-2-capryloyl-sn-glycero-3-phosphocholine | 1-Palmitoyl-2-capryloyl-sn-glycero-3-phosphocholine (PC(16:0/8:0)) is a phosphatidylcholine glycerophospholipid. 1-Palmitoyl-2-capryloyl-sn-glycero-3-phosphocholine promotes platelet aggregation and flow-induced platelet-dependent thrombus formation. 1-Palmitoyl-2-capryloyl-sn-glycero-3-phosphocholine is a valid biomarker for CAD risk, severity, and subtype differentiation. 1-Palmitoyl-2-capryloyl-sn-glycero-3-phosphocholine is suitable for basic research on various types of coronary artery disease. | |||||||||||||||||||||
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(S)-1,2-Dilauroyl-sn-glycero-3-phosphocholine | (S)-1,2-Dilauroyl-sn-glycero-3-phosphocholine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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11:0 PC | 11:0 PC (1,2-Diundecanoyl-sn-glycero-3-phosphocholine) is a phosphatidylcholine, which plays a role in the folding of intact, functionally competent integral membrane proteins. | |||||||||||||||||||||
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References
- [1]. Chen S, et al. The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3. J Lipid Res. 2024;65(2):100499. [Content Brief]
- [2]. Dong Y, et al. Oxidized phospholipids as novel mediators of neurodegeneration. Trends Neurosci. 2022;45(6):419-429. [Content Brief]
- [3]. Fruhwirth GO, et al. The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells. Biochim Biophys Acta. 2006;1761(9):1060-1069. [Content Brief]
