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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
structural transitions
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "structural transitions" in MCE Product Catalog:
Cat. No.: HY-149136
CAS No.: 2412688-16-3
Target:
Research Areas:
MORF-627 is a highly selective, orally active integrin αvβ6 inhibitor. By blocking TGF-β1 activation and pSMAD2 signaling, MORF-627 significantly reduces collagen deposition, epithelial-mesenchymal transition markers, and structural changes in fibrotic cells. MORF-627 exhibits significant antifibrotic efficacy without genotoxicity in idiopathic pulmonary fibrosis models. However, MORF-627 induces bladder epithelial proliferation and early invasive urothelial carcinoma in cynomolgus monkeys and human cells, and this toxic effect can be reversed by exogenous TGF-β. MORF-627 can be used for studying the pathological mechanisms of pulmonary fibrosis and evaluating drug safety .
Cat. No.: HY-124339
CAS No.: 2092913-64-7
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JNJ525 is a TNFα inhibitor with IC50 values of 1.2 μM and 1.1 μM against TNFR1 and TNFR2, respectively. JNJ525 forms ordered aggregates and induces quaternary structural transition of TNFα, thereby blocking the protein-protein interaction between TNFα and its receptors. The inhibitory activity of JNJ525 is completely lost in the presence of 0.1% Triton X-100 .
Cat. No.: HY-172403
CAS No.: 25608-40-6
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Poly-L-aspartic acid is an acidic polypeptide that functions via pH-dependent conformational changes. Poly-L-aspartic acid is promising for research of pH-responsive structural transitions in biological systems .
Cat. No.: HY-P11457
CAS No.: 2378579-44-1
Cat. No.: HY-W1060365
CAS No.: 2089-12-5
Research Areas:
4-((Aminooxy)methyl)phenol is an Indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor with a human IC50 of 61 μM. 4-((Aminooxy)methyl)phenol inhibits IDO1 catalytic activity and acts as a structural mimic of the enzyme's alkylperoxy transition or intermediate state. 4-((Aminooxy)methyl)phenol can be used for the research of cancer .
Cat. No.: HY-D3152
CAS No.: 2361979-91-9
Cat. No.: HY-K6504
MCE Human iPSC/ESC Cortical Brain Organoid Maturation Medium is a ready-to-use culture system specifically formulated for the long-term maintenance and maturation of cortical brain organoids. It serves as a seamless transition from the induction phase and supports the continued growth and functional development of the organoids. Upon switching PSC-derived cortical brain organoids to this medium, organoid viability and structural stability are markedly enhanced, enabling a robust and extended culture period of up to 180 d.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
