5 Results for "

toxic aldehyde accumulation

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "toxic aldehyde accumulation" in MCE Product Catalog:

KS100
KS100
0 Images
Cat. No.: HY-146682
CAS No.: 2408477-54-1
Purity:  99.61%
Target:  

Aldehyde Dehydrogenase (ALDH) Apoptosis

Research Areas:  

Cancer

KS100 is a potent ALDH inhibitor with IC50s of 230, 1542, 193 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS100 shows antiproliferative and anticancer effects with low low toxic. KS100 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS10600 induces apoptosis and cell cycle arrest at the G2/M phase .
loading...
    loading...
View All Sizes
KS106
KS106
0 Images
Cat. No.: HY-146683
CAS No.: 2408477-50-7
Purity:  99.31%
Target:  

Aldehyde Dehydrogenase (ALDH) Apoptosis

Research Areas:  

Cancer

KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase .
loading...
    loading...
View All Sizes
PVA (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization)
PVA (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization)
0 Images
Cat. No.: HY-Y0850U1
CAS No.: 9002-89-5
Synonyms: Polyvinyl alcohol (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization); Poly(Ethenol) (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization)
PVA (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization) is a semicrystalline and biocompatible synthetic polymer with excellent safety properties including non-toxicity, no accumulation, and non-mutagenicity. PVA (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization) undergoes cross-linking via acetal bond formation between hydroxyl and aldehyde groups, and it can be used to prepare highly rigid, low-solubility degradable films as well as for dry or minimally invasive in vitro wound studies. PVA (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization) can construct a hydroxyl-rich microenvironment to trap photogenerated holes, thereby promoting hydrogen peroxide production and enhancing the redox cycle of iron species in the photo-Fenton reaction. PVA (Mw 61000, 98-99% hydrolyzed, ~1400 polymerization) can act as a sacrificial agent and substrate to achieve synchronous degradation with pollutants, and it is applicable to sustainable waste management and water treatment .
loading...
    loading...
View All Sizes
Cyanamide-15N2
Cyanamide-15N2
0 Images
Cat. No.: HY-W720629
CAS No.: 21420-37-1
Cyanamide- 15N2 is the 15N-labeled Cyanamide (HY-Y0070). Cyanamide is a cell division and plant growth inhibitor, as well as an allelochemical derived from Vicia villosa. Cyanamide inhibits root growth and biomass accumulation in a dose-dependent manner by disrupting the formation of mitotic spindles and phragmoplast complexes, reducing the number of mitotic cells and blocking the cell cycle. The effects of Cyanamide are partially reversible after removal from low-concentration environments. Cyanamide is also a specific inhibitor of aldehyde dehydrogenase (ALDH). Although Cyanamide has no direct effect on tumor growth, it can significantly enhance the anti-tumor efficacy of Cyclophosphamide (HY-17420) at non-toxic doses by inhibiting the inactivation of Cyclophosphamide. Cyanamide enables Cyclophosphamide to exert equivalent therapeutic effects at lower doses, effectively inhibiting the growth of primary and metastatic tumors and prolonging the lifespan of tumor-bearing mice. Cyanamide is commonly used in studies related to ha-1 hepatoma and rls lymphosarcoma .
loading...
    loading...
View All Sizes
Cyanamide
Cyanamide
0 Images
Cat. No.: HY-Y0070
CAS No.: 420-04-2
Cyanamide is a cell division and plant growth inhibitor, as well as an allelochemical derived from Vicia villosa. Cyanamide inhibits root growth and biomass accumulation in a dose-dependent manner by disrupting the formation of mitotic spindles and phragmoplast complexes, reducing the number of mitotic cells and blocking the cell cycle. The effects of Cyanamide are partially reversible after removal from low-concentration environments. Cyanamide is also a specific inhibitor of aldehyde dehydrogenase (ALDH). Although Cyanamide has no direct effect on tumor growth, it can significantly enhance the anti-tumor efficacy of Cyclophosphamide (HY-17420) at non-toxic doses by inhibiting the inactivation of Cyclophosphamide. Cyanamide enables Cyclophosphamide to exert equivalent therapeutic effects at lower doses, effectively inhibiting the growth of primary and metastatic tumors and prolonging the lifespan of tumor-bearing mice. Cyanamide is commonly used in studies related to ha-1 hepatoma and rls lymphosarcoma .
loading...
    loading...
View All Sizes
Assay Types