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Cat. No.: HY-32735C

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(14R)-Triptolide

(Synonyms: (14R)-PG490)

(14R)-Triptolide ((14R)-PG490) (Compound T59) is a Triptolide (HY-32735) derivative. (14R)-Triptolide shows anti-cancer activity against multiple cancer cells with IC₅₀ of 0.477-2.53 μM. (14R)-Triptolide can be used for the research of cancer, such as ovarian cancer and colon cancer.

For research use only. We do not sell to patients.

CAS No.: 144539-79-7
Formula: C₂₀H₂₄O₆
Molecular Weight:360.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

(14R)-Triptolide Chemical Structure

CAS No.: 144539-79-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.059 μg/mL Compound: 11	Cytotoxicity against human A549 lung tumor cells Cytotoxicity against human A549 lung tumor cells	[PMID: 16455242]
A549	IC₅₀	59 ng/mL Compound: 1b, 14-epi-triptolide	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 18321701]
HT-29	IC₅₀	0.0091 μg/mL Compound: 11	Cytotoxicity against human HT29 colon tumor cells Cytotoxicity against human HT29 colon tumor cells	[PMID: 16455242]
HT-29	IC₅₀	9.1 ng/mL Compound: 1b, 14-epi-triptolide	Cytotoxicity against human HT29 cells Cytotoxicity against human HT29 cells	[PMID: 18321701]
MDA-MB-468	IC₅₀	1.32 μM Compound: 2	Cytotoxicity against human MDA-MB-468 cells by SRB assay Cytotoxicity against human MDA-MB-468 cells by SRB assay	[PMID: 19637874]
PC-3	IC₅₀	1.6 μM Compound: 2	Cytotoxicity against human PC3 cells by SRB assay Cytotoxicity against human PC3 cells by SRB assay	[PMID: 19637874]
PC-3	IC₅₀	1320 nM Compound: 2	Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay	[PMID: 24378709]
SK-OV-3	IC₅₀	0.79 μM Compound: 2	Cytotoxicity against human SKOV3 cells by SRB assay Cytotoxicity against human SKOV3 cells by SRB assay	[PMID: 19637874]
SK-OV-3	IC₅₀	790 nM Compound: 2	Cytotoxicity against human SKOV3 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human SKOV3 cells after 72 hrs by sulforhodamine B assay	[PMID: 24378709]

Chemical Information

CAS No. 144539-79-7
Molecular Weight 360.40
Formula C₂₀H₂₄O₆
SMILES

C[C@@]12[C@@]34[C@]5([C@H]([C@@]6([C@](O6)([H])[C@]3([H])O4)C(C)C)O)[C@@](C[C@@]1([H])C7=C(C(OC7)=O)CC2)([H])O5
Synonyms

(14R)-PG490
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. DanYang, et al. Polycyclic epoxides and compositions thereof with anti-cancer activities. WO2016181312A1. 2017-11-11

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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