Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities

  • Bioorg Med Chem Lett. 2006 Apr 1;16(7):1947-9. doi: 10.1016/j.bmcl.2005.12.098.
Yutaka Aoyagi  1 ,  Yukio Hitotsuyanagi ,  Tomoyo Hasuda ,  Haruhiko Fukaya ,  Koichi Takeya ,  Ritsuo Aiyama ,  Takeshi Matsuzaki ,  Shusuke Hashimoto
Affiliations
  • 1. School of Pharmacy, Tokyo University of Pharmacy & Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
PMID: 16455242 DOI: 10.1016/j.bmcl.2005.12.098
Abstract

Several C-ring modified analogues of a potent antileukemic diterpene, triptolide (1), were synthesized and their structure-activity relationships were studied.