MitoTam iodide, hydriodide
Based on 1 Customer Validation
MitoTam iodide, hydriodide is a Tamoxifen derivative, an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology. MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells. MitoTam iodide, hydriodide causes apoptosis.
For research use only. We do not sell to patients.
- Purity: 95.66%
- CAS No.: 1634624-74-0
- Formula: C52H60I2NOP
- Molecular Weight:999.82
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Storage:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Apoptosis Compound Library
HY-L003
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Metabolism/Protease Compound Library
HY-L012
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Stem Cell Signaling Compound Library
HY-L017
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Reprogramming Compound Library
HY-L039
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Glutamine Metabolism Compound Library
HY-L064
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Cancer Metabolism Compound Library
HY-L083
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Anti-Parkinson's Disease Compound Library
HY-L085
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Neurodegenerative Disease-related Compound Library
HY-L086
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Mitochondria-Targeted Compound Library
HY-L089
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Glucose Metabolism Compound Library
HY-L092
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Cuproptosis Compound Library
HY-L133
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Cancer Stem Cells Compound Library
HY-L135
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Mitochondrial Protection Compound Library
HY-L144
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Metabolic Enzyme Compound Library
HY-L146
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Cell Death Library
HY-L162
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MCE Bioactive Compound Library
HY-L001V
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Protein Kinase Compound Library
HY-L196
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
MitoTam (0.5 μM-56 μM; 24 hours) kills breast cancer cell Lines and nonmalignant cells with an IC50 range from 0.65 μM to 55.9 μM[1]. MitoTam (2.5 μM; 2-24 hours) results in stronger activation of the apoptotic pathway in MCF7 Her2high cells compared with mock MCF7 cells[1]. MitoTam (0.05 μM-1 μM; 3 days) causes a concentration-dependent induction of apoptosis in breast cancer cells, while there was no effect for non-malignant breast epithelial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Breast Cancer Cell Lines: BT474, MCF7, MCF7 Her2high, MCF7 Her2low, MDA-MB-231, MDA-MB-436, MDA-MB-453, SK-BR-3, T47D; NeuTL cells; Nonmalignant Cells: A014578, H9c2 cells
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Concentration:0.5 μM-56 μM
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Incubation Time:24 hours
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Result:Killed breast cancer cells MCF7, MCF7 Her2high, MCF7 Her2low with IC50 values of 1.25 μM, 0.65 μM and 1.45 μM respectively.
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Cell Line:MCF7 mock and MCF7 Her2high cells
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Concentration:2.5 μM
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Incubation Time:2 hours, 4 hours, 8 hours, 16 hours, 24 hours
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Result:Revealed accelerated cleavage of procaspase-9, Parp1/2 and proapoptotic Bax and decreased the antiapoptotic Bcl-2 protein in Her2high cells.
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Cell Line:MCF-7, 4T1 and MCF-10a cells
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Concentration:0.05 μM-1 μM
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Incubation Time:3 days
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Result:Resulted in apoptosis in MCF7 and 4T1 cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:18-month-old or 2-month-old FVB/N mice[1]
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Dosage:2 μg/g
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Administration:Intraperitoneal injection; 2 μg/g; once a week; 4 weeks
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Result:Eliminated senescent cells also in vivo.
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Animal Model:18-month-old or 2-month-old FVB/N mice[2]
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Dosage:0.54 μmol/mouse
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Administration:Intraperitoneal injection; 0.54 μmol/mouse; twice a week; 2 weeks
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Result:Suppressed Her2high breast carcinomas.
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Animal Model:18-month-old or 2-month-old FVB/N mice[1]
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Dosage:0.25 μmol/mouse
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Administration:Intraperitoneal injection; 0.25 μmol/mouse; twice a week; 2 weeks
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Result:Prevented reaching the ethical endpoint in all situations, slowed down the growth of MCF7 mock tumors and suppressed Her2high carcinomas decreased.
Chemical Information
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CAS No. 1634624-74-0
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Appearance Solid
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Molecular Weight 999.82
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Formula C52H60I2NOP
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Color White to light yellow
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SMILES
CN(CCOC1=CC=C(/C(C2=CC=CC=C2)=C(C3=CC=CC=C3)/CCCCCCCCCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)C=C1)C.[H]I.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (100.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Rohlenova K, et al. Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2highBreast Cancer. Antioxid Redox Signal. 2017 Jan 10;26(2):84-103. [Content Brief]
[2]. Hubackova S, et al. Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2. Cell Death Differ. 2019 Jan;26(2):276-290. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0002 mL | 5.0009 mL | 10.0018 mL | 25.0045 mL |
| 5 mM | 0.2000 mL | 1.0002 mL | 2.0004 mL | 5.0009 mL | |
| 10 mM | 0.1000 mL | 0.5001 mL | 1.0002 mL | 2.5005 mL | |
| 15 mM | 0.0667 mL | 0.3334 mL | 0.6668 mL | 1.6670 mL | |
| 20 mM | 0.0500 mL | 0.2500 mL | 0.5001 mL | 1.2502 mL | |
| 25 mM | 0.0400 mL | 0.2000 mL | 0.4001 mL | 1.0002 mL | |
| 30 mM | 0.0333 mL | 0.1667 mL | 0.3334 mL | 0.8335 mL | |
| 40 mM | 0.0250 mL | 0.1250 mL | 0.2500 mL | 0.6251 mL | |
| 50 mM | 0.0200 mL | 0.1000 mL | 0.2000 mL | 0.5001 mL | |
| 60 mM | 0.0167 mL | 0.0833 mL | 0.1667 mL | 0.4167 mL | |
| 80 mM | 0.0125 mL | 0.0625 mL | 0.1250 mL | 0.3126 mL | |
| 100 mM | 0.0100 mL | 0.0500 mL | 0.1000 mL | 0.2500 mL |
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