2. Immunology/Inflammation
  3. Scavenger Receptor Class B type I (SR-BI）
  4. SMS121

SMS121 is a CD36 inhibitor with a KD values of about 5 µM. SMS121 reduces the uptake of lipids and inhibits cell viability in acute myeloid leukemia cells. SMS121 has antitumor activity.

For research use only. We do not sell to patients.

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

SMS121 Related Antibodies

Top Publications Citing Use of Products

    SMS121 purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2025 Jul 8:S0002-9440(25)00235-4.  [Abstract]

    Transwell assay performed with primary liver immune cells in the insert and LMac in the bottom chamber. Treatment with or without CD5L neutralizing antibody or CD36 inhibitor SMS121 (200 μM) is compared with vehicle treatment (0.1% FBS).

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    SMS121 is a CD36 inhibitor with a KD values of about 5 µM. SMS121 reduces the uptake of lipids and inhibits cell viability in acute myeloid leukemia cells. SMS121 has antitumor activity[1].

    IC50 & Target

    CD36[1]
    In Vitro

    SMS121 (0-500 µM; 50 min) inhibits lipid uptake in KG-1 cells with an IC50 of 164 µM[1].
    SMS121 (0-400 µM; 72 h) inhibits the viability of KG-1 cells with an IC50 of 156 µM[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SMS121 Related Antibodies

    Immunofluorescence[1]

    Cell Line: BODIPY fluorescent fatty acid analogue treated KG-1 cell
    Concentration: 200 µM
    Incubation Time: 50 min
    Result: Significantly reduced green fluorescence compared to control group.
    Molecular Weight

    355.38

    Formula

    C20H21NO5
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    O=C(O)COC1=CC=C(/C=C/C(C2=CC=C(N(C)C)C=C2)=O)C=C1OC
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 13.33 mg/mL (37.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8139 mL 14.0694 mL 28.1389 mL
    5 mM 0.5628 mL 2.8139 mL 5.6278 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

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    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 1.33 mg/mL (3.74 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.33 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 1.33 mg/mL (3.74 mM); Clear solution

      This protocol yields a clear solution of ≥ 1.33 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.8139 mL 14.0694 mL 28.1389 mL 70.3472 mL
    5 mM 0.5628 mL 2.8139 mL 5.6278 mL 14.0694 mL
    10 mM 0.2814 mL 1.4069 mL 2.8139 mL 7.0347 mL
    15 mM 0.1876 mL 0.9380 mL 1.8759 mL 4.6898 mL
    20 mM 0.1407 mL 0.7035 mL 1.4069 mL 3.5174 mL
    25 mM 0.1126 mL 0.5628 mL 1.1256 mL 2.8139 mL
    30 mM 0.0938 mL 0.4690 mL 0.9380 mL 2.3449 mL
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    SMS121 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SMS121SMS 121SMS-121Scavenger Receptor Class B type I (SR-BI）Scavenger receptor class B member 1SRB1CD36 and LIMPII analogous 1 (CLA-1)CD36 antigen-like 1Fatty acidsAMLKG-1 cellsInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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