SMS121

Name: SMS121
Brand: MedChemExpress
SKU: HY-163541
Rating: 5.0 (3 reviews)

Cat. No.: HY-163541 Pureza: 99.06%: Ficha de datos
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SDS
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SMS121 is a CD36 inhibitor with a K_D values of about 5 µM. SMS121 reduces the uptake of lipids and inhibits cell viability in acute myeloid leukemia cells. SMS121 has antitumor activity.

Para uso exclusivo en investigación. No vendemos a pacientes.

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	Obtener un presupuesto
100 mg	Obtener un presupuesto

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Revisión del cliente

Based on 3 publication(s) in Google Scholar

3 Publications Citing Use of MCE SMS121

Cell Migration/Invasion Assay

: SMS121 purchased from MedChemExpress. Usage Cited in: Am J Pathol. 2025 Jul 8:S0002-9440(25)00235-4. [Abstract]; Transwell assay performed with primary liver immune cells in the insert and LMac in the bottom chamber. Treatment with or without CD5L neutralizing antibody or CD36 inhibitor SMS121 (200 μM) is compared with vehicle treatment (0.1% FBS).

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Descripciòn

SMS121 is a CD36 inhibitor with a K_D values of about 5 µM. SMS121 reduces the uptake of lipids and inhibits cell viability in acute myeloid leukemia cells. SMS121 has antitumor activity^[1].

IC₅₀ & Target

CD36^[1]

In Vitro

SMS121 (0-500 µM; 50 min) inhibits lipid uptake in KG-1 cells with an IC₅₀ of 164 µM^[1].
SMS121 (0-400 µM; 72 h) inhibits the viability of KG-1 cells with an IC₅₀ of 156 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:	BODIPY fluorescent fatty acid analogue treated KG-1 cell
Concentration:	200 µM
Incubation Time:	50 min
Result:	Significantly reduced green fluorescence compared to control group.

Peso molecular

355.38

Fòrmula

C₂₀H₂₁NO₅

Appearance

Solid

Color

White to yellow

SMILES

O=C(O)COC1=CC=C(/C=C/C(C2=CC=C(N(C)C)C=C2)=O)C=C1OC

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 13.33 mg/mL (37.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8139 mL	14.0694 mL	28.1389 mL
5 mM	0.5628 mL	2.8139 mL	5.6278 mL
10 mM	0.2814 mL	1.4069 mL	2.8139 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.33 mg/mL (3.74 mM); Clear solution

This protocol yields a clear solution of ≥ 1.33 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.33 mg/mL (3.74 mM); Clear solution

This protocol yields a clear solution of ≥ 1.33 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.33 mg/mL (3.74 mM); Clear solution

This protocol yields a clear solution of ≥ 1.33 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (13.3 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Pureza y Documentación

Purity: 99.06%

Select Batch:

Ficha de datos (271 KB) SDS (251 KB)

COA (244 KB) HNMR (138 KB) RP-HPLC (253 KB) LCMS (234 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Åbacka H, et al. SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia[J]. Scientific Reports, 2024, 14(1): 9104. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8139 mL	14.0694 mL	28.1389 mL	70.3472 mL
	5 mM	0.5628 mL	2.8139 mL	5.6278 mL	14.0694 mL
	10 mM	0.2814 mL	1.4069 mL	2.8139 mL	7.0347 mL
	15 mM	0.1876 mL	0.9380 mL	1.8759 mL	4.6898 mL
	20 mM	0.1407 mL	0.7035 mL	1.4069 mL	3.5174 mL
	25 mM	0.1126 mL	0.5628 mL	1.1256 mL	2.8139 mL
	30 mM	0.0938 mL	0.4690 mL	0.9380 mL	2.3449 mL

SMS121 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMS121SMS 121SMS-121Scavenger Receptor Class B type I (SR-BI）Scavenger receptor class B member 1SRB1CD36 and LIMPII analogous 1 (CLA-1)CD36 antigen-like 1Fatty acidsAMLKG-1 cellsInhibitorinhibitorinhibit

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SMS121

Revisión del cliente

SMS121 Related Antibodies

3 Publications Citing Use of MCE SMS121

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

SMS121 Related Antibodies

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

SMS121 Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

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SAFETY DATA SHEET (SDS)

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