1. Metabolic Enzyme/Protease
  2. Mitochondrial Metabolism
  3. T0467

T0467 

Cat. No.: HY-139308
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T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research.

For research use only. We do not sell to patients.

T0467 Chemical Structure

T0467 Chemical Structure

CAS No. : 859518-94-8

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Description

T0467 activates parkin mitochondrial translocation in a PINK1-dependent manner in vitro. T0467 do not induce mitochondrial accumulation of PINK1in dopaminergic neurons. T0467 is a potential compound for PINK1-Parkin signaling activation, and can be used for parkinson's disease and related disorders research[1].

In Vitro

T0467 (2.5-20 μM; 3 hours) stimulates the mitochondrial translocation of GFP-Parkinover 12 μM in HeLa/GFP-Parkin cells[1]. When HeLa/GFP-Parkin cells are treated with 20 μM T0467 for 3 h, GTP-Parkin is translocated to the mitochondria in approximately 21% of cells[1].
T0467 does not show obvious toxicity in Drosophila at concentrations <50 μM. All cpds examined mitigated the PINK1 inactivation-mediated larval locomotion defects and mitochondrial morphological defects and reduced ATP production. T0467 and KTP improved the mitochondrial Ca2+ response in Drosophila larval muscles[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

441.49

Formula

C₂₄H₂₆F₃N₅

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T0467
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