FCCP (Standard)
Based on 1 publication(s) in Google Scholar
FCCP (Standard) is the analytical standard of FCCP. This product is intended for research and analytical applications. FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.
For research use only. We do not sell to patients.
- Purity: 99.21%
- CAS No.: 370-86-5
- Formula: C10H5F3N4O
- Molecular Weight:254.17
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) FCCP (Standard)
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Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 370-86-5
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Appearance Solid
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Molecular Weight 254.17
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Formula C10H5F3N4O
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Color Light yellow to yellow
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SMILES
N#C/C(C#N)=N/NC1=CC=C(OC(F)(F)F)C=C1
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Synonyms
Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Virol
Coronavirus infectious bronchitis virus spike protein inhibits FUNDC1-mediated mitophagy to prevent nucleocapsid protein degradation. [Abstract]2026 May 19;100(5):e0180025. PMID: 42007729
Purity & Documentation
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
[1]. Connop BP et al.Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing. J Neurochem. 1999 Apr;72(4):1457-65. [Content Brief]
[2]. Tanpradit N, et al. Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) pre-exposure ensures follicle integrity during in vitro culture of ovarian tissue but not during cryopreservation in the domestic cat model. J Assist Reprod Genet. 2016 Dec;33(12):1621-1631. Epub 2016 Sep 17. [Content Brief]
[3]. Kondapalli C, et al. PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol. 2012 May;2(5):120080. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)