Taribavirin hydrochloride
Based on 1 Customer Validation
Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. Taribavirin hydrochloride is a Ribavirin proagent, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 40372-00-7
- Formula: C8H14ClN5O4
- Molecular Weight:279.68
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Anti-Hematopathy Compound Library
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Anti-Infection Compound Library
HY-L002
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Antiviral Compound Library
HY-L027
Biological Activity
Inosine monophosphate dehydrogenase[1]
Taribavirin hydrochloride (0-2 μM; 24 hours) significantly induces MCF-7 cell death, recording half inhibitory effect (IC50) of 0.756 μM in MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7 cells
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Concentration:0 μM, 0.1 μM, 1 μM, 2 μM
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Incubation Time:24 hours
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Result:Decreased MCF-7 cell growth.
Chemical Information
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CAS No. 40372-00-7
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Appearance Solid
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Molecular Weight 279.68
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Formula C8H14ClN5O4
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Color White to off-white
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SMILES
N=C(C1=NN([C@H]2[C@@H]([C@@H]([C@@H](CO)O2)O)O)C=N1)N.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (357.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Abd-Rabou AA, et al. Taribavirin and 5-Fluorouracil-Loaded Pegylated-Lipid Nanoparticle Synthesis, p38 Docking, and Antiproliferative Effects on MCF-7 Breast Cancer. Pharm Res. 2018 Feb 27;35(4):76. [Content Brief]
[2]. Deming P, et al. Taribavirin in the treatment of hepatitis C. Expert Opin Investig Drugs. 2011 Oct;20(10):1435-43. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5755 mL | 17.8776 mL | 35.7551 mL | 89.3879 mL |
| 5 mM | 0.7151 mL | 3.5755 mL | 7.1510 mL | 17.8776 mL | |
| 10 mM | 0.3576 mL | 1.7878 mL | 3.5755 mL | 8.9388 mL | |
| 15 mM | 0.2384 mL | 1.1918 mL | 2.3837 mL | 5.9592 mL | |
| 20 mM | 0.1788 mL | 0.8939 mL | 1.7878 mL | 4.4694 mL | |
| 25 mM | 0.1430 mL | 0.7151 mL | 1.4302 mL | 3.5755 mL | |
| 30 mM | 0.1192 mL | 0.5959 mL | 1.1918 mL | 2.9796 mL | |
| 40 mM | 0.0894 mL | 0.4469 mL | 0.8939 mL | 2.2347 mL | |
| 50 mM | 0.0715 mL | 0.3576 mL | 0.7151 mL | 1.7878 mL | |
| 60 mM | 0.0596 mL | 0.2980 mL | 0.5959 mL | 1.4898 mL | |
| 80 mM | 0.0447 mL | 0.2235 mL | 0.4469 mL | 1.1173 mL | |
| 100 mM | 0.0358 mL | 0.1788 mL | 0.3576 mL | 0.8939 mL |
Taribavirin hydrochloride Related Classifications
HY-10545A Related Classifications
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