1. Anti-infection
  2. HBV HCV
  3. Taribavirin hydrochloride

Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. Taribavirin hydrochloride is a Ribavirin proagent, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia.

For research use only. We do not sell to patients.

Taribavirin hydrochloride Chemical Structure

Taribavirin hydrochloride Chemical Structure

CAS No. : 40372-00-7

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Based on 1 publication(s) in Google Scholar

Other Forms of Taribavirin hydrochloride:

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. Taribavirin hydrochloride is a Ribavirin proagent, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia[2].

IC50 & Target

Inosine monophosphate dehydrogenase[1]

In Vitro

Taribavirin hydrochloride (0-2 μM; 24 hours) significantly induces MCF-7 cell death, recording half inhibitory effect (IC50) of 0.756 μM in MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 0 μM, 0.1 μM, 1 μM, 2 μM
Incubation Time: 24 hours
Result: Decreased MCF-7 cell growth.
Clinical Trial
Molecular Weight

279.68

Formula

C8H14ClN5O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N=C(C1=NN([C@H]2[C@@H]([C@@H]([C@@H](CO)O2)O)O)C=N1)N.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (357.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5755 mL 17.8776 mL 35.7551 mL
5 mM 0.7151 mL 3.5755 mL 7.1510 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.96%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5755 mL 17.8776 mL 35.7551 mL 89.3879 mL
5 mM 0.7151 mL 3.5755 mL 7.1510 mL 17.8776 mL
10 mM 0.3576 mL 1.7878 mL 3.5755 mL 8.9388 mL
15 mM 0.2384 mL 1.1918 mL 2.3837 mL 5.9592 mL
20 mM 0.1788 mL 0.8939 mL 1.7878 mL 4.4694 mL
25 mM 0.1430 mL 0.7151 mL 1.4302 mL 3.5755 mL
30 mM 0.1192 mL 0.5959 mL 1.1918 mL 2.9796 mL
40 mM 0.0894 mL 0.4469 mL 0.8939 mL 2.2347 mL
50 mM 0.0715 mL 0.3576 mL 0.7151 mL 1.7878 mL
60 mM 0.0596 mL 0.2980 mL 0.5959 mL 1.4898 mL
80 mM 0.0447 mL 0.2235 mL 0.4469 mL 1.1173 mL
100 mM 0.0358 mL 0.1788 mL 0.3576 mL 0.8939 mL
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Taribavirin hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Taribavirin hydrochloride
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