Argifin
Based on 1 Customer Validation
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 243975-37-3
- Formula: C29H41N9O10
- Molecular Weight:675.69
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Biological Activity
IC50: 0.025 μM (SmChiA), 6.4 μM (SmChiB), 1.1 μM (Aspergillus fumigatus chitinase B1), 4.5 μM (human chitotriosidase)[1]
Argifin inhibits L. cuprina chitinase with IC50 values of 3.7 μM at 37 oC and 0.10 μM at 20 oC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cyclo({d-Ala}-{N5-[imino[[(methylamino)carbonyl]amino]methyl]-L-ornithyl}-{Phe(Me)}-{Bas}-{Bas})
Cyclo({d-Ala}-{N5-[imino[[(methylamino)carbonyl]amino]methyl]-L-ornithyl}-{Phe(Me)}-{Bas}-{Bas})
Chemical Information
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CAS No. 243975-37-3
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Appearance Solid
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Molecular Weight 675.69
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Formula C29H41N9O10
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Color White to off-white
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Structure Classification
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Initial Source
Gliocladium sp
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (148.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4800 mL | 7.3998 mL | 14.7997 mL | 36.9992 mL |
| 5 mM | 0.2960 mL | 1.4800 mL | 2.9599 mL | 7.3998 mL | |
| 10 mM | 0.1480 mL | 0.7400 mL | 1.4800 mL | 3.6999 mL | |
| 15 mM | 0.0987 mL | 0.4933 mL | 0.9866 mL | 2.4666 mL | |
| 20 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8500 mL | |
| 25 mM | 0.0592 mL | 0.2960 mL | 0.5920 mL | 1.4800 mL | |
| 30 mM | 0.0493 mL | 0.2467 mL | 0.4933 mL | 1.2333 mL | |
| 40 mM | 0.0370 mL | 0.1850 mL | 0.3700 mL | 0.9250 mL | |
| 50 mM | 0.0296 mL | 0.1480 mL | 0.2960 mL | 0.7400 mL | |
| 60 mM | 0.0247 mL | 0.1233 mL | 0.2467 mL | 0.6167 mL | |
| 80 mM | 0.0185 mL | 0.0925 mL | 0.1850 mL | 0.4625 mL | |
| 100 mM | 0.0148 mL | 0.0740 mL | 0.1480 mL | 0.3700 mL |
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