BNIP3L - BCL2 interacting protein 3 like Gene

Also Known as NIX; BNIP3a

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 665

About BNIP3L

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,383,054-26,413,127 (from NCBI)

This gene has 7 transcripts (splice variants), 312 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 69.4), ovary (RPKM 49.9) and 24 other tissues.

Summary

This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 Family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]

BNIP3L Products (2)

mRNA Protein Name
NM_001330491.2 NP_001317420.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2
NM_004331.3 NP_004322.1 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
10381623 GOA
enables lamin binding IDA
IDA: Inferred from direct assay
10381623 GOA
enables lamin binding IPI
IPI: Inferred from physical interaction
10381623 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9973195 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
10381623 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to hypoxia IGI
IGI: Inferred from genetic interaction
19273585 GOA
involved in defense response to virus IDA
IDA: Inferred from direct assay
9973195 GOA
involved in mitochondrial protein catabolic process IMP
IMP: Inferred from mutant phenotype
21264228 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
10381623 GOA
acts upstream of or within negative regulation of programmed cell death IGI
IGI: Inferred from genetic interaction
19273585 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
9973195 GOA
acts upstream of or within positive regulation of macroautophagy IGI
IGI: Inferred from genetic interaction
19273585 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10381623 GOA
located in mitochondrial outer membrane IMP
IMP: Inferred from mutant phenotype
21264228 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
9973195 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
10381623 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BNIP3L Protein Structure

BNIP3

BNIP3: BNIP3 (29 - 219)

  • 0
  • 100
  • 200
  • 219 a.a.
Protein Preferred Names Protein Names

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

  • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A

BNIP3L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BNIP3L O60238 LDLRAD1 Homo sapiens Q5T700
Y2H Array
31515488
Intra
BNIP3L O60238 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
25416956
Intra
BNIP3L O60238 LDLRAD1 Homo sapiens Q5T700
Validated Y2H
25416956
Intra
BNIP3L O60238 TMPRSS4 Homo sapiens Q9NRS4
Validated Y2H
32296183
Intra
BNIP3L O60238 CLEC7A Homo sapiens Q9BXN2-6
Y2H Array
32296183
Intra
BNIP3L O60238 CLEC7A Homo sapiens Q9BXN2-6
Y2H Prey Pooling
32296183
Intra
BNIP3L O60238 CLEC7A Homo sapiens Q9BXN2-6
Validated Y2H
32296183
Intra
BNIP3L O60238 TNMD Homo sapiens Q9H2S6-2
Validated Y2H
32296183
Intra
BNIP3L O60238 NR4A1 Homo sapiens P22736-1
Pull Down
24316735
Intra
BNIP3L O60238 NR4A1 Homo sapiens P22736-1
Anti Tag CoIP
24316735
Cross
BNIP3L O60238 ORF10 SARS-CoV-2 A0A663DJA2
Anti Tag CoIP
34845370
Cross
BNIP3L O60238 ORF10 SARS-CoV-2 A0A663DJA2
Confocal
34845370
Intra
BNIP3L O60238 CLEC7A Homo sapiens Q9BXN2
Y2H Array
25416956
Intra
BNIP3L O60238 CLEC7A Homo sapiens Q9BXN2
Y2H
21516116
Intra
BNIP3L O60238 CLEC7A Homo sapiens Q9BXN2
Y2H Prey Pooling
25416956
Intra
BNIP3L O60238 ATP13A2 Homo sapiens Q9NQ11
Anti Tag CoIP
22645275
Intra
BNIP3L O60238 BAD Homo sapiens Q92934
Pull Down
9973195
Intra
BNIP3L O60238 GABARAPL2 Homo sapiens P60520
Validated Y2H
32296183
Intra
BNIP3L O60238 TMEM11 Homo sapiens P17152
Validated Y2H
32296183
Intra
BNIP3L O60238 TMEM11 Homo sapiens P17152
Y2H Array
25416956
Intra
BNIP3L O60238 TMEM11 Homo sapiens P17152
Y2H Pooling
16189514
Intra
BNIP3L O60238 TMEM11 Homo sapiens P17152
Validated Y2H
27107012
Intra
BNIP3L O60238 TMEM11 Homo sapiens P17152
Y2H Prey Pooling
25416956
Intra
BNIP3L O60238 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra
BNIP3L O60238 FATE1 Homo sapiens Q969F0
Y2H Array
25416956
Intra
BNIP3L O60238 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
32296183
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
BFG-2H
27107012
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
Y2H Array
19060904
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
TAP
24981860
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
Validated Y2H
32296183
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
Y2H
10381623
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
Beta Galactosidase
10381623
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
Y2H Pooling
19060904
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
Y2H Array
32296183
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
Y2H Prey Pooling
25416956
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
Y2H Prey Pooling
32296183
Intra
BNIP3L O60238 BNIP3 Homo sapiens Q12983
Anti Tag CoIP
10381623
Intra
BNIP3L O60238 MALL Homo sapiens Q13021
Validated Y2H
32296183
Intra
BNIP3L O60238 BCL2 Homo sapiens P10415
Pull Down
9973195
Intra
BNIP3L O60238 BNIP3L Homo sapiens O60238
Y2H
10381623
Intra
BNIP3L O60238 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra
BNIP3L O60238 SMCO4 Homo sapiens Q9NRQ5
Y2H Array
25416956
Intra
BNIP3L O60238 SMCO4 Homo sapiens Q9NRQ5
Y2H
21516116
Intra
BNIP3L O60238 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
25416956
Cross
BNIP3L O60238 E1B Human adenovirus C P03247
Y2H
10381623
Cross
BNIP3L O60238 E1B Human adenovirus C P03247
Pull Down
9973195
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BNIP3L Proteins

Cat. No. Product Name Accession Purity
HY-P75471 BNIP3L Protein, Human NP_004322.1 (S2-K187) ≥ 90%, as determined by reducing SDS-PAGE.

BNIP3L Antibodies

Cat. No. Product Name Application Reactivity
HY-P80571 BNIP3L Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Pediculus Humanus Capitis Infestation

  • Pediculosis Capitis

  • Pediculus Capitis Infestation

  • Head Louse Infestation

  • Pediculus Capitis

  • Head-Louse Infestation

  • Head Lice

  • Infestation By Pediculus Capitis
Lice Infestation

  • Pediculosis

  • Louse Infestation

  • Mixed Pediculosis

  • Lice Infestations

  • Infestation By Pediculus

  • Mixed Pediculosis Infestation

  • Pediculosis + Lice

  • Pediculosis And Phthirus Infection

  • Pediculosis And Phthirus Infections

  • Pediculosis And Phthirus Infestation

  • Infestation By Anoplura

  • Pediculus Infestation

  • Lice Nos
Asbestos-Related Lung Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01565 BNIP3L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18697 Bnip3l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25184 Bnip3l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BNIP3L MGD MGI:1332659
Rattus norvegicus BNIP3L RGD RGD:621354
Bos taurus BNIP3L VGNC VGNC:26534
Macaca mulatta BNIP3L VGNC VGNC:70274
Felis catus BNIP3L VGNC VGNC:78457
Others BNIP3L NCBI