Musk - muscle associated receptor tyrosine kinase Gene

Also Known as Nsk1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81725

Summary

Enables protein kinase binding activity and protein tyrosine kinase activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of synaptic transmission; and sensory organ development. Located in cell projection; external side of plasma membrane; and neuromuscular junction. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 9 and fetal akinesia deformation sequence syndrome 1. Orthologous to human MUSK (muscle associated receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Musk Products (1)

mRNA Protein Name
NM_031061.2 NP_112323.2 muscle, skeletal receptor tyrosine protein kinase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15604144 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16818610 RGD
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
12220490 RGD
Biological Process GO Annotation Evidence References Source
involved in cochlea development IEP
IEP: Inferred from expression pattern
18420419 RGD
involved in long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
16870737 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
16870737 RGD
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
15604144 RGD
involved in neuromuscular junction development IEP
IEP: Inferred from expression pattern
7546737 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
16870737 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
18436384 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
18436384 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
16870737 RGD
involved in positive regulation of synaptic assembly at neuromuscular junction IMP
IMP: Inferred from mutant phenotype
14749715 RGD
involved in positive regulation of synaptic transmission, cholinergic IMP
IMP: Inferred from mutant phenotype
16870737 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
16818610 RGD
involved in receptor clustering IMP
IMP: Inferred from mutant phenotype
16818610 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
9698449 RGD
involved in response to electrical stimulus IMP
IMP: Inferred from mutant phenotype
16870737 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
9698449 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
16899069 RGD
Cellular Component GO Annotation Evidence References Source
located in cell projection IDA
IDA: Inferred from direct assay
16899069 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17011580 RGD
located in neuromuscular junction IDA
IDA: Inferred from direct assay
9698449 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muscle, skeletal receptor tyrosine protein kinase

  • muscle specific kinase (neural fold/somite kinase 1)

  • muscle, skeletal, receptor tyrosine kinase

  • muscle-specific kinase receptor

  • muscle-specific tyrosine kinase receptor MuSK

  • muscle-specific tyrosine protein kinase receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0287 Clomiphene / Unkown

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991066 Adimanebart 99.739% Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0633 Muscone Inhibitor 98.0% Unkown
HY-15590 AZ-23 Inhibitor 98.92% Unkown
HY-N3127 Orobol Inhibitor 99.74% Unkown
HY-W100026 Galaxolide 76.44% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-N2045 Musk ketone 99.21% Unkown
HY-W744618 Ambrettolide 99.53% Unkown
HY-W721109 (R)-(-)-Muscone Agonist 98.61% Unkown
HY-116108 Musk tibetene Ligand 98.0% Unkown
HY-RS08852 MUSK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-171982 ATII / Unkown
HY-RS17455 Musk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23912 Musk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990473 Anti-MUSK Antibody Inhibitor 99.81% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Musk NCBI NCBI:4593