GX-936
Based on 1 Customer Validation
GX-936 (PF-05196233), a potent and Nav1.7-subtype selective inhibitor, binds to the activated state of voltage-sensor domain IV (VSD4).
For research use only. We do not sell to patients.
- Purity: 97.06%
- CAS No.: 1235406-09-3
- Formula: C24H20F3N7O3S2
- Molecular Weight:575.59
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1235406-09-3
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Appearance Solid
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Molecular Weight 575.59
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Formula C24H20F3N7O3S2
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Color White to light yellow
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SMILES
O=S(C1=CC=C(C(C#N)=C1)OC2=CC=C(C=C2C3=CC=NN3C4CN(C4)CC)C(F)(F)F)(NC5=NC=NS5)=O
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Synonyms
PF-05196233
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : ≥ 75 mg/mL (130.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. R Ian Storer, et al. Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4805-4811. [Content Brief]
[2]. Shivani Ahuja, et al. Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist. Science. 2015 Dec 18;350(6267):aac5464. [Content Brief]
[3]. Jian Payandeh, et al. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7. Handb Exp Pharmacol. 2018:246:271-306. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7373 mL | 8.6867 mL | 17.3735 mL | 43.4337 mL |
| 5 mM | 0.3475 mL | 1.7373 mL | 3.4747 mL | 8.6867 mL | |
| 10 mM | 0.1737 mL | 0.8687 mL | 1.7373 mL | 4.3434 mL | |
| 15 mM | 0.1158 mL | 0.5791 mL | 1.1582 mL | 2.8956 mL | |
| 20 mM | 0.0869 mL | 0.4343 mL | 0.8687 mL | 2.1717 mL | |
| 25 mM | 0.0695 mL | 0.3475 mL | 0.6949 mL | 1.7373 mL | |
| 30 mM | 0.0579 mL | 0.2896 mL | 0.5791 mL | 1.4478 mL | |
| 40 mM | 0.0434 mL | 0.2172 mL | 0.4343 mL | 1.0858 mL | |
| 50 mM | 0.0347 mL | 0.1737 mL | 0.3475 mL | 0.8687 mL | |
| 60 mM | 0.0290 mL | 0.1448 mL | 0.2896 mL | 0.7239 mL | |
| 80 mM | 0.0217 mL | 0.1086 mL | 0.2172 mL | 0.5429 mL | |
| 100 mM | 0.0174 mL | 0.0869 mL | 0.1737 mL | 0.4343 mL |
GX-936 Related Classifications
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