RID-F
RID-F (Ridaifen-F), a Tamoxifen (HY-13757A) derivative, is a nonpeptidic proteasome inhibitor. RID-F inhibits human 20S proteasome activity, with IC50s of 0.64, 0.34, and 0.43 μM for CT-L, T-L, and PGPH, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1020853-03-5
- Formula: C38H50N2O2
- Molecular Weight:566.82
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
4.38 μM
Compound: 6, RID-F, Ridaifen-F
|
Cytotoxicity against ER-negative HEK293 cells after 48 hrs by MTT assay
Cytotoxicity against ER-negative HEK293 cells after 48 hrs by MTT assay
|
[PMID: 24321833] |
| HL-60 | CC50 |
3.42 μM
Compound: 6, RID-F, Ridaifen-F
|
Cytotoxicity against ER-positive human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against ER-positive human HL60 cells after 48 hrs by MTT assay
|
[PMID: 24321833] |
| RPMI-8226 | CC50 |
3.6 μM
Compound: 1
|
Cytotoxicity against human RPMI8226 cells after 24 to 48 hrs by CellTiter-Glo assay
Cytotoxicity against human RPMI8226 cells after 24 to 48 hrs by CellTiter-Glo assay
|
[PMID: 29407987] |
Chemical Information
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CAS No. 1020853-03-5
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Molecular Weight 566.82
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Formula C38H50N2O2
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SMILES
CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN3CCCCCC3)C=C2)\C4=CC=C(OCCN5CCCCCC5)C=C4
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Synonyms
Ridaifen-F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)