TMEM175 agonist 3
TMEM175 agonist 3 (Compound 123) is a TMEM175 agonist, with an EC50 of 0.044 μM in human TMEM175 FLIPR assays and an EC50 of 0.073 μM in human TMEM175 EP assays. TMEM175 agonist 3 can be used in the research of Parkinson's disease, dementia with Lewy bodies, rapid eye movement sleep behavior disorder, amyotrophic lateral sclerosis, and lysosomal storage diseases.
For research use only. We do not sell to patients.
- CAS No.: 3129652-66-7
- Formula: C24H21N5O4S
- Molecular Weight:475.52
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
TMEM175 is a bifunctional channel protein on the lysosomal membrane with both proton and potassium ion permeability. It maintains lysosomal homeostasis and α-synuclein degradation, and its loss-of-function mutations significantly increase the risk of Parkinson's disease.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3129652-66-7
-
Molecular Weight 475.52
-
Formula C24H21N5O4S
-
SMILES
O=C1N(NS(C2=CC3=C(C=CN3)C=C2)(=O)=O)C([C@@H](C4=CC=CC=C4)OC)=NC5=C1C=CN=C5C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TMEM175 agonist 3 Related Classifications
HY-186257 Related Classifications
Powered by Bioz