1. Membrane Transporter/Ion Channel
  2. P-glycoprotein
  3. WS-898

WS-898 is a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC50 = 5.0, 3.67, and 3.68 nM, respectively).

For research use only. We do not sell to patients.

WS-898 Chemical Structure

WS-898 Chemical Structure

CAS No. : 2891562-77-7

Size Price Stock Quantity
5 mg USD 510 In-stock
10 mg USD 820 In-stock
25 mg USD 1640 In-stock
50 mg USD 2620 In-stock
100 mg USD 4190 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

WS-898 is a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC50 = 5.0, 3.67, and 3.68 nM, respectively).

Molecular Weight

567.66

Formula

C33H25N7OS

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(/C=C/C1=CC=C(C=CC=C2)C2=C1)C3=CC=C(NC4=CC(C)=NC5=NC(SCC6=NC7=C(C=CC=C7)N6)=NN54)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 25 mg/mL (44.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7616 mL 8.8081 mL 17.6162 mL
5 mM 0.3523 mL 1.7616 mL 3.5232 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.14%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7616 mL 8.8081 mL 17.6162 mL 44.0404 mL
5 mM 0.3523 mL 1.7616 mL 3.5232 mL 8.8081 mL
10 mM 0.1762 mL 0.8808 mL 1.7616 mL 4.4040 mL
15 mM 0.1174 mL 0.5872 mL 1.1744 mL 2.9360 mL
20 mM 0.0881 mL 0.4404 mL 0.8808 mL 2.2020 mL
25 mM 0.0705 mL 0.3523 mL 0.7046 mL 1.7616 mL
30 mM 0.0587 mL 0.2936 mL 0.5872 mL 1.4680 mL
40 mM 0.0440 mL 0.2202 mL 0.4404 mL 1.1010 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

WS-898 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
WS-898
Cat. No.:
HY-139848
Quantity:
MCE Japan Authorized Agent: