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4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer.

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4′-Bromoflavone Chemical Structure

4′-Bromoflavone Chemical Structure

CAS No. : 20525-20-6

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Description

4′-Bromoflavone, a cancer chemopreventive agent, is a potent phase II detoxification enzymes inducer[1].

In Vitro

4′-Bromoflavone significantly induces quinone reductase (QR) activity in cultured murine hepatoma 1c1c7 cells (concentration to double activity: 10 nM) and effectively induces the α- and mu-isoforms of glutathione S-transferase in cultured H4IIE rat hepatoma cells with no observed toxicity[1].
4′-Bromoflavone is a potent inhibitor of cytochrome P4501A1-mediated ethoxyresorufin-O-deethylase activity, with an IC50 of 0.86 μM. In HepG2 or MCF-7 cells, 4′-Bromoflavone significantly reduces the covalent binding of metabolically activated benzo[a]pyrene to cellular DNA[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In short-term dietary studies, 4′-Bromoflavone is also shown to increase QR activity and glutathione levels in rat liver, mammary gland, colon, stomach, and lung in a dose-dependent manner. In studies conducted with female Sprague Dawley rats ,4′-Bromoflavone significantly increases QR activity (phase II enzyme)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

301.13

Formula

C15H9BrO2

CAS No.
SMILES

O=C1C=C(C2=CC=C(Br)C=C2)OC3=CC=CC=C13

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4′-Bromoflavone Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
4′-Bromoflavone
Cat. No.:
HY-115772
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