CCT129202
Based on 1 Customer Validation
CCT129202 is an aurora kinase inhibitor with IC50s of 42, 198, and 227 nM for aurora A, B and C, respectively.
For research use only. We do not sell to patients.
- Purity : 99.62%
- CAS No.: 942947-93-5
- Formula: C23H25ClN8OS
- Molecular Weight:497.02
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-12003
SNS-314 mesylateAurora Kinase Inhibitor -
HY-10179
DanusertibAurora Kinase Inhibitor -
HY-10971
AlisertibAurora A Kinase Inhibitor -
HY-10126
Barasertib-HQPAAurora B Inhibitor -
HY-12201
TAK-901 -
HY-10178
PHA-680632Aurora Kinase Inhibitor -
HY-10128
ZM-447439Aurora A/B Inhibitor -
HY-10180
MLN8054Aurora A Inhibitor -
HY-10161
TozasertibAurora A/B/C Inhibitor -
HY-10558
CYC-116aurora A/B Inhibitor -
HY-10987A
ENMD-2076 -
HY-10329
JNJ-7706621Aurora Kinase/CDK Inhibitor
All Aurora Kinase Isoforms
More
Biological Activity
Description
IC50 & Target
[1]|
Aurora A 42 nM (IC50) |
Aurora B 198 nM (IC50) |
Aurora C 227 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HCT-116 | GI50 |
0.35 μM
Compound: 7
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Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
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[PMID: 20565112] |
| HCT-116 | GI50 |
0.35 μM
Compound: 31
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Antiproliferative activity against HCT116 cells
Antiproliferative activity against HCT116 cells
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[PMID: 17933533] |
| HeLa | GI50 |
0.2 μM
Compound: 31
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Antiproliferative activity against HeLa cells
Antiproliferative activity against HeLa cells
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[PMID: 17933533] |
In Vitro
CCT129202 causes the accumulation of human tumor cells with z4N DNA content, leading to apoptosis. CCT129202 is found to induce apoptosis with GI50 values that ranges between 0.08 and 1.7 μM. CCT120202-treated human tumor cells shows a delay in mitosis, abrogation of nocodazole-induced mitotic arrest, and spindle defects. CCT129202 Causes p21Up-regulation, Rb Hypophosphorylation, and H2F-DependentTK1Down-regulation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 942947-93-5
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Appearance Solid
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Molecular Weight 497.02
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Formula C23H25ClN8OS
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Color Light yellow to yellow
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SMILES
CN(C1=CC=C(C2=NC3=C(C(Cl)=CN=C3N2)N4CCN(CC4)CC(NC5=NC=CS5)=O)C=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 1 mg/mL (2.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0120 mL | 10.0600 mL | 20.1199 mL | 50.2998 mL |
CCT129202 Related Classifications
HY-12049 Related Classifications
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