1. MAPK/ERK Pathway
  2. JNK
  3. D-JNKI-1

D-JNKI-1 (Synonyms: AM-111; XG-102)

Cat. No.: HY-P0069 Purity: 97.25%
Handling Instructions

D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.

For research use only. We do not sell to patients.

D-JNKI-1 Chemical Structure

D-JNKI-1 Chemical Structure

CAS No. : 1445179-97-4

Size Price Stock Quantity
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 360 In-stock
Estimated Time of Arrival: December 31
10 mg USD 540 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1380 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 2 publication(s) in Google Scholar

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D-JNKI-1 (AM-111) is a highly potent and cell-permeable peptide inhibitor of JNK.

IC50 & Target[1]



In Vitro

D-JNKI-1 (AM-111; 1 μM-1 mM) treatment prevents apoptosis and loss of neomycin-exposed hair cells[1].

In Vivo

D-JNKI-1 (AM-111; 10 μM) prevents nearly all hair cell death and permanent hearing loss induced by neomycin ototoxicity in the scala tympani of the guinea pig cochlea. Local delivery of D-JNKI-1 also prevents acoustic trauma-induced permanent hearing loss in a dose-dependent manner[1]. D-JNKI-1 (0.3 mg/kg, i.p.) reverses these pathological events in the brain mitochondria of the rat and almost completely abolishes cytochrome c release and PARP cleavage[2]. D-JNKI-1 (1 μg/kg, s.c.) results in a significant decrease in the disease activity index, and reduces the expression of CD4+ and CD8+ cells in mice[3].

Clinical Trial
Molecular Weight








Sequence Shortening





Room temperature in continental US; may vary elsewhere.

Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (13.08 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2616 mL 1.3081 mL 2.6161 mL
5 mM 0.0523 mL 0.2616 mL 0.5232 mL
10 mM 0.0262 mL 0.1308 mL 0.2616 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    D-JNKI-1 is dissolved in double distilled water[4].

Animal Administration

D-JNKI-1 is dissolved in a 0.9% sodium chloride solution for subcutaneous application. Each group (the 1.0% DSS group and the 1.5% DSS group) is randomly subdivided into an intervention group (n = 15) and a control group (n = 15). The mice in the intervention group receive three subcutaneous nuchal administrations of 1 μg/kg D-JNKI-1 on days 2, 12, and 22. The mice in the control group receive physiological saline subcutaneously as a negative control at the same time points in a comparable stress situation.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: 97.25%

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D-JNKI-1AM-111XG-102AM111AM 111XG102XG 102JNKc-Jun N-terminal kinaseInhibitorinhibitorinhibit

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