1. MAPK/ERK Pathway
  2. Ribosomal S6 Kinase (RSK)
  3. FMK-MEA

FMK-MEA 

Cat. No.: HY-52101C
Handling Instructions

FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.

For research use only. We do not sell to patients.

FMK-MEA Chemical Structure

FMK-MEA Chemical Structure

CAS No. : 1414811-15-6

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Description

FMK-MEA is a potent and selective p90 Ribosomal S6 Kinase (RSK) inhibitor.

IC50 & Target

p90 RSK[1]

In Vitro

FMK-MEA is a water-soluble derivative of fmk. FMK-MEA treatment inhibits RSK2 kinase activity in diverse, highly invasive human cancer cell lines including 212LN, M4e, A549, and SKBR3 cells. Treatment with the RSK-specific inhibitor FMK-MEA significantly attenuates RSK2 activity, as assessed by the phosphorylation levels of Ser-386 and the consequent invasive ability of A549 cells[1].

In Vivo

FMK-MEA treatment (80 mg/kg/day for 16 days by intraperitoneal injection) in highly metastatic M4e cell xenograft nude mice results in a significant attenuation of LN metastasis. FMK-MEA treatment has no effect on the tumor size, and the proliferation rate of the primary tumor[1].

Molecular Weight

399.46

Formula

C₂₁H₂₆FN₅O₂

CAS No.

1414811-15-6

SMILES

FCC(C1=C(C2=CC=C(C)C=C2)C3=C(N)N=CN=C3N1CCCNCCOC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[1]

Mice[1]

For FMK-MEA treatment, each of the nude mice (athymic nu/nu, female, 4-6 weeks old) are injected with 0.5×106cells/100 μL of PBS submandibular to the mylohyoid muscle. On day 5 after injection, mice are divided into two groups with similar average weights with each group receiving either FMK-MEA or PBS. Each mouse is administered 80 mg/kg of FMK-MEA daily by intraperitoneal injection from 5 days after the xenograft for 16 days total. The control group receives PBS alone on the same schedule. Tumor growth is recorded. Mice are sacrificed after 16 days post drug treatment[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

FMK-MEARibosomal S6 Kinase (RSK)S6KInhibitorinhibitorinhibit

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