1. Neuronal Signaling
  2. Monoamine Oxidase
  3. Moclobemide

Moclobemide (Synonyms: Ro111163)

Cat. No.: HY-B0534 Purity: 99.63%
Handling Instructions

Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

For research use only. We do not sell to patients.

Moclobemide Chemical Structure

Moclobemide Chemical Structure

CAS No. : 71320-77-9

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10 mM * 1 mL in DMSO USD 183 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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Estimated Time of Arrival: December 31
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Description

Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

IC50 & Target

MAO-A

6.061 (IC50)

In Vitro

NMDA (600 µM for 3 days) inhibits the proliferation of PC12 cells.Moclobemide (2 and 10 µM) up-regulates the proliferation in NMDA-treated PC12 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[2]

Cell Line: PC12 cell line
Concentration: Moclobemide (2 and 10 µM); N-methylaspartate (NMDA) (600 µM)
Incubation Time: 3 days
Result: Treatment with NMDA significantly reduced the percentage of S-phase, while the percentage of other cell cycle phases did not change notablely.However,the percentage of S-phase increased in the presence of Moclobemide.
In Vivo

Moclobemide is a monoamine oxidase inhibitor and increases the levels of brain monoamines (such as 5-HT, norepinephrine).Moclobemide(40 mg/kg) is effective in animal behavior models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chronically stressed male mice (18±2 g) of the Kunming strain[2]
Dosage: 40 mg/kg
Administration: I.p.; daily
Result: BDNF level in the hippocampal subfields including subgranule zone decreased in stressed mice compared with normal control. Chronic treatment with Moclobemide could reverse these changes.
Clinical Trial
Molecular Weight

268.74

Formula

C13H17ClN2O2

CAS No.
SMILES

O=C(NCCN1CCOCC1)C2=CC=C(Cl)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (372.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7211 mL 18.6053 mL 37.2107 mL
5 mM 0.7442 mL 3.7211 mL 7.4421 mL
10 mM 0.3721 mL 1.8605 mL 3.7211 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.30 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.30 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.30 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Moclobemide
Cat. No.:
HY-B0534
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