1. Protein Tyrosine Kinase/RTK
  2. Pyk2
    FAK

PF-431396 

Cat. No.: HY-10460 Purity: 99.15%
Handling Instructions

PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4.

For research use only. We do not sell to patients.
PF-431396 Chemical Structure

PF-431396 Chemical Structure

CAS No. : 717906-29-1

Size Stock
10 mM * 1 mL in DMSO Get quote
10 mg USD 108 Get quote
50 mg USD 336 Get quote
100 mg USD 540 Get quote
200 mg USD 1020 Get quote

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    PF-431396 purchased from MCE. Usage Cited in: J Periodontal Res. 2015 Dec;50(6):855-863.

    PF431396 inhibits the phosphorylation of FAK and Akt.
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively), PF-431396 has a Kd value of 445 nM for BRD4. IC50 value: 2 nM (FAK); 11 nM (PYK2); 445 nM (KD for BRD4) [1] [2] Target: FAK; PYK2; BRD4 in vitro: PF-431396 is a potent and highly selective pyrimidine-based inhibitor of both Pyk2 and FAK, Consistent with the idea that the tyrosine phosphorylation of Pyk2 and FAK involves an initial autophosphorylation or transphosphorylation step, treating A20 cells with PF-431396 blocked anti-Ig-induced tyrosine phosphorylation of Pyk2 and FAK when the cells were stimulated in suspension when they were stimulated on ECM [3]. Nanomolar affinities were also determined for PF-431396 (Kd = 445 ± 42 nM) and for the PIM inhibitor (Kd = 565 ± 63 nM) [2].

    References
    Molecular Weight

    506.5

    Formula

    C₂₂H₂₁F₃N₆O₃S

    CAS No.

    717906-29-1

    SMILES

    CS(=O)(N(C)C1=CC=CC=C1CNC2=NC(NC3=CC4=C(C=C3)NC(C4)=O)=NC=C2C(F)(F)F)=O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    PF-431396
    Cat. No.:
    HY-10460
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