PF-431396 (Standard)
PF-431396 (Standard) is the analytical standard of PF-431396 (HY-10460). This product is intended for research and analytical applications. PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC50 values of 2 nM and 11 nM, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 717906-29-1
- Fòrmula: C22H21F3N6O3S
- Peso molecular:506.50
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Pureza y Documentación
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Help & FAQs
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HY-10460
PF-431396Pyk2/FAK Inhibitor -
HY-10459
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HY-12289
DefactinibFAK Inhibitor -
HY-100498
GSK2256098FAK Inhibitor -
HY-13203
NVP-TAE 226Apoptosis Inducer -
HY-13917
PND-1186FAK Inhibitor -
HY-10458
PF-562271 (besylate)FAK/Pyk2 Inhibitor -
HY-20403
PF-562271 hydrochlorideFAK/Pyk2 Inhibitor -
HY-12289A
Defactinib hydrochlorideFAK Inhibitor -
HY-18312
PF-4618433PYK2 Inhibitor
Product Information
Information
Aplicación
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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No. CAS 717906-29-1
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Peso molecular 506.50
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Fòrmula C22H21F3N6O3S
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SMILES
CS(=O)(N(C)C1=CC=CC=C1CNC2=NC(NC3=CC4=C(C=C3)NC(C4)=O)=NC=C2C(F)(F)F)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Seungil Han, et al. Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design. J Biol Chem. 2009 May 8; 284(19): 13193–13201. [Content Brief]
[2]. Ciceri P, et al. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat Chem Biol. 2014 Mar 2. [Content Brief]
[3]. Tse KW, et al. B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J Biol Chem. 2009 Aug 21;284(34):22865-77. [Content Brief]
[4]. Leonard Buckbinder, et al. Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10619-24. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-431396 (Standard) Related Classifications
HY-10460R Related Classifications
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