1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR

Savolitinib (Synonyms: Volitinib; HMPL-504; AZD-6094)

Cat. No.: HY-15959 Purity: 99.78%
Handling Instructions

Savolitinib(Volitinib; AZD-6094; Volitinib) is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase(IC50= 5 nM) with potential antineoplastic activity.

For research use only. We do not sell to patients.
Savolitinib Chemical Structure

Savolitinib Chemical Structure

CAS No. : 1313725-88-0

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 238 In-stock
5 mg USD 216 In-stock
10 mg USD 336 In-stock
50 mg USD 840 In-stock
100 mg USD 1320 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Savolitinib(Volitinib; AZD-6094; Volitinib) is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase(IC50= 5 nM) with potential antineoplastic activity. IC50 value: 5 nM [1] Target: Volitinib demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.Volitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress the c-Met protein. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase and plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis; this protein is overexpressed or mutated in a variety of cancers.

Clinical Trial
References
Molecular Weight

345.36

Formula

C₁₇H₁₅N₉

CAS No.

1313725-88-0

SMILES

CN1N=CC(C2=CN=C3C(N([[email protected]](C4=CN5C(C=C4)=NC=C5)C)N=N3)=N2)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 34 mg/mL

Volitinib is dissolved in a dosing vehicle composed of DMSO, PEG400, and distilled water (5:45:50%, v/v/v) at the concentration of 1 mg/mL[3].

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

References

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Savolitinib
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