1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR

Savolitinib (Synonyms: Volitinib; HMPL-504; AZD-6094)

Cat. No.: HY-15959 Purity: 98.45%
Handling Instructions

Savolitinib(Volitinib; AZD-6094; Volitinib) is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase(IC50= 5 nM) with potential antineoplastic activity.

For research use only. We do not sell to patients.

Savolitinib Chemical Structure

Savolitinib Chemical Structure

CAS No. : 1313725-88-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 238 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 216 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 336 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 840 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1320 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Savolitinib(Volitinib; AZD-6094; Volitinib) is an orally bioavailable inhibitor of the c-Met receptor tyrosine kinase(IC50= 5 nM) with potential antineoplastic activity. IC50 value: 5 nM [1] Target: Volitinib demonstrated favorable pharmacokinetic properties in mice and good antitumor activities in the human glioma xenograft model in athymic nude mice.Volitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress the c-Met protein. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase and plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis; this protein is overexpressed or mutated in a variety of cancers.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (98.45 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8955 mL 14.4776 mL 28.9553 mL
5 mM 0.5791 mL 2.8955 mL 5.7911 mL
10 mM 0.2896 mL 1.4478 mL 2.8955 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Volitinib is dissolved in a dosing vehicle composed of DMSO, PEG400, and distilled water (5:45:50%, v/v/v) at the concentration of 1 mg/mL[3].

References
Molecular Weight

345.36

Formula

C₁₇H₁₅N₉

CAS No.

1313725-88-0

SMILES

CN1N=CC(C2=CN=C3C(N([[email protected]](C4=CN5C(C=C4)=NC=C5)C)N=N3)=N2)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Savolitinib
Cat. No.:
HY-15959
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Savolitinib

Cat. No.: HY-15959