PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4095)
Related Products (4095)
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PROTAC Linkers Isoform Comparison
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endo-BCN-PEG8-NHS ester
0 ImagesCat. No.: HY-140070CAS No.: 1608140-48-2
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Fmoc-NH-PEG6-CH2COOH
0 ImagesFmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Boc-Hyp-OH
0 ImagesBoc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2]-
3-Iodopropan-1-ol
0 ImagesSynonyms: 3-Iodopropan-1-ol
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Biotin-PEG2-NHS ester
0 ImagesCat. No.: HY-140888CAS No.: 596820-83-6
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Bromo-PEG2-C2-Boc
0 ImagesCat. No.: HY-141365CAS No.: 1381861-91-1
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Azido-PEG12-acid
0 ImagesAzido-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG12-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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tert-Butyl trans-4-aminocyclohexanecarboxylate
0 ImagesCat. No.: HY-W249520CAS No.: 1022159-15-4
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2-(Piperidin-4-yl)ethan-1-ol
0 ImagesCat. No.: HY-W012729CAS No.: 622-26-4Synonyms: 4-Piperidineethanol
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3-(tert-Butoxycarbonyl)-3-azaspiro[5.5]undecane-9-carboxylic acid
![3-(tert-Butoxycarbonyl)-3-azaspiro[5.5]undecane-9-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w059721.gif "Click to View 3-(tert-Butoxycarbonyl)-3-azaspiro[5.5]undecane-9-carboxylic acid Product Detail")
0 ImagesCat. No.: HY-W059721CAS No.: 170228-81-6
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tert-Butyl N-{3-formylbicyclo[1.1.1]pentan-1-yl}carbamate
![tert-Butyl N-{3-formylbicyclo[1.1.1]pentan-1-yl}carbamate](https://file.medchemexpress.com/product_pic/hy-w056049.gif "Click to View tert-Butyl N-{3-formylbicyclo[1.1.1]pentan-1-yl}carbamate Product Detail")
0 ImagesCat. No.: HY-W056049CAS No.: 1638771-06-8
![tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-30605.gif "Click to View tert-Butyl 2,8-diazaspiro[4.5]decane-2-carboxylate Product Detail")
