PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
![4-[(Piperidin-4-yl)oxy]piperidine-1-carboxylic acid tert-butyl ester](https://file.medchemexpress.com/product_pic/hy-22026.gif "Click to View 4-[(Piperidin-4-yl)oxy]piperidine-1-carboxylic acid tert-butyl ester Product Detail")
![Boc-(7-Azaspiro[3.5]nonane)-NH2](https://file.medchemexpress.com/product_pic/hy-w022388.gif "Click to View Boc-(7-Azaspiro[3.5]nonane)-NH2 Product Detail")
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7-(tert-Butoxy)-7-oxoheptanoic acid
0 ImagesCat. No.: HY-W108876CAS No.: 1469894-57-2
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Biotin-PEG11-Mal
0 ImagesCat. No.: HY-140909CAS No.: 1646619-56-8
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Boc-C14-COOH
0 ImagesBoc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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Azido-PEG2-C6-Cl
0 ImagesCat. No.: HY-138470CAS No.: 2568146-55-2Azido-PEG2-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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20-(tert-Butoxy)-20-oxoicosanoic acid
0 Images20-(tert-Butoxy)-20-oxoicosanoic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 20-(tert-Butoxy)-20-oxoicosanoic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs-
Tetrazine-Ph-PEG5-NHS ester
0 ImagesTetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
