PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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H-Hyp-OMe hydrochloride
0 ImagesH-Hyp-OMe hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Hyp-OMe hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]<
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t-Butyl acetate-PEG2-CH2COOH
0 ImagesCat. No.: HY-W096080CAS No.: 883564-93-0
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Biotin-PEG4-amide-Alkyne
0 ImagesCat. No.: HY-140923CAS No.: 1006592-45-5
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Mal-PEG36-NHS ester
0 ImagesCat. No.: HY-133389CAS No.: 2136297-07-7
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N-Boc-PEG8-alcohol
0 ImagesCat. No.: HY-141192CAS No.: 1345337-22-5
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Amino-PEG10-Boc
0 ImagesCat. No.: HY-140196CAS No.: 1818294-42-6
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m-PEG12-OH
0 Imagesm-PEG12-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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UV Cleavable Biotin-PEG2-Azide
0 ImagesCat. No.: HY-140920CAS No.: 1192802-98-4UV Cleavable Biotin-PEG2-Azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. UV Cleavable Biotin-PEG2-Azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
