Biotin-PEG8-acid
Based on 1 Customer Validation
Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 98.17%
- CAS No.: 2143964-62-7
- Formula: C29H53N3O12S
- Molecular Weight:667.81
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2143964-62-7
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Appearance Solid
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Molecular Weight 667.81
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Formula C29H53N3O12S
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Color White to off-white
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SMILES
O=C(O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 116.67 mg/mL (174.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4974 mL | 7.4872 mL | 14.9743 mL | 37.4358 mL |
| 5 mM | 0.2995 mL | 1.4974 mL | 2.9949 mL | 7.4872 mL | |
| 10 mM | 0.1497 mL | 0.7487 mL | 1.4974 mL | 3.7436 mL | |
| 15 mM | 0.0998 mL | 0.4991 mL | 0.9983 mL | 2.4957 mL | |
| 20 mM | 0.0749 mL | 0.3744 mL | 0.7487 mL | 1.8718 mL | |
| 25 mM | 0.0599 mL | 0.2995 mL | 0.5990 mL | 1.4974 mL | |
| 30 mM | 0.0499 mL | 0.2496 mL | 0.4991 mL | 1.2479 mL | |
| 40 mM | 0.0374 mL | 0.1872 mL | 0.3744 mL | 0.9359 mL | |
| 50 mM | 0.0299 mL | 0.1497 mL | 0.2995 mL | 0.7487 mL | |
| 60 mM | 0.0250 mL | 0.1248 mL | 0.2496 mL | 0.6239 mL | |
| 80 mM | 0.0187 mL | 0.0936 mL | 0.1872 mL | 0.4679 mL | |
| 100 mM | 0.0150 mL | 0.0749 mL | 0.1497 mL | 0.3744 mL |
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