Biotin-PEG-Biotin
Based on 1 Customer Validation
Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.32%
- CAS No.: 194920-55-3
- Formula: C26H44N6O6S2
- Molecular Weight:600.79
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 194920-55-3
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Appearance Solid
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Molecular Weight 600.79
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Formula C26H44N6O6S2
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Color Off-white to light yellow
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SMILES
O=C(NCCOCCOCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O)CCCC[C@@H]3SC[C@]([C@]3([H])N4)([H])NC4=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 175 mg/mL (291.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6645 mL | 8.3224 mL | 16.6448 mL | 41.6119 mL |
| 5 mM | 0.3329 mL | 1.6645 mL | 3.3290 mL | 8.3224 mL | |
| 10 mM | 0.1664 mL | 0.8322 mL | 1.6645 mL | 4.1612 mL | |
| 15 mM | 0.1110 mL | 0.5548 mL | 1.1097 mL | 2.7741 mL | |
| 20 mM | 0.0832 mL | 0.4161 mL | 0.8322 mL | 2.0806 mL | |
| 25 mM | 0.0666 mL | 0.3329 mL | 0.6658 mL | 1.6645 mL | |
| 30 mM | 0.0555 mL | 0.2774 mL | 0.5548 mL | 1.3871 mL | |
| 40 mM | 0.0416 mL | 0.2081 mL | 0.4161 mL | 1.0403 mL | |
| 50 mM | 0.0333 mL | 0.1664 mL | 0.3329 mL | 0.8322 mL | |
| 60 mM | 0.0277 mL | 0.1387 mL | 0.2774 mL | 0.6935 mL | |
| 80 mM | 0.0208 mL | 0.1040 mL | 0.2081 mL | 0.5201 mL | |
| 100 mM | 0.0166 mL | 0.0832 mL | 0.1664 mL | 0.4161 mL |
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