PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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Boc-NH-PEG1-CH2CH2COOH
0 ImagesBoc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs.
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Amino-PEG3-C2-acid
0 ImagesAmino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG3-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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BocNH-PEG5-CH2CH2Br
0 ImagesCat. No.: HY-W096092CAS No.: 1392499-33-0
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Boc-NH-PEG2
0 ImagesSynonyms: PROTAC Linker 11
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Mal-PEG3-NH2 TFA
0 ImagesMal-PEG3-NH2 TFA is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 TFA is a crosslinking reagent with a PEG spacer.
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2-Chloroethanamine hydrochloride
0 ImagesCat. No.: HY-W012901CAS No.: 870-24-6Synonyms: 2-Chloroethylammonium chloride
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m-PEG4-Amine
0 Imagesm-PEG4-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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Br-PEG3-C2-Boc
0 ImagesCat. No.: HY-130483CAS No.: 782475-37-0
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m-PEG12-amine
0 Imagesm-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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TCO-PEG8-NHS ester
0 ImagesCat. No.: HY-141169CAS No.: 2353409-95-5
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Methyl 2-(4-formylphenyl)acetate
0 ImagesCat. No.: HY-59040CAS No.: 96524-70-8
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tert-Butyl hex-5-yn-1-ylcarbamate
0 ImagesCat. No.: HY-W050829CAS No.: 151978-58-4
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Methyl 5-aminovalerate hydrochloride
0 ImagesCat. No.: HY-21271CAS No.: 29840-56-0
