TCO-PEG8-NHS ester
Based on 1 Customer Validation
TCO-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2353409-95-5
- Formula: C32H54N2O14
- Molecular Weight:690.78
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2353409-95-5
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Appearance Viscous Liquid
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Molecular Weight 690.78
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Formula C32H54N2O14
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Color Colorless to light yellow
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SMILES
O=C(OC1CC/C=C\CCC1)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : ≥ 100 mg/mL (144.76 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.4476 mL | 7.2382 mL | 14.4764 mL | 36.1910 mL |
| 5 mM | 0.2895 mL | 1.4476 mL | 2.8953 mL | 7.2382 mL | |
| 10 mM | 0.1448 mL | 0.7238 mL | 1.4476 mL | 3.6191 mL | |
| 15 mM | 0.0965 mL | 0.4825 mL | 0.9651 mL | 2.4127 mL | |
| 20 mM | 0.0724 mL | 0.3619 mL | 0.7238 mL | 1.8095 mL | |
| 25 mM | 0.0579 mL | 0.2895 mL | 0.5791 mL | 1.4476 mL | |
| 30 mM | 0.0483 mL | 0.2413 mL | 0.4825 mL | 1.2064 mL | |
| 40 mM | 0.0362 mL | 0.1810 mL | 0.3619 mL | 0.9048 mL | |
| 50 mM | 0.0290 mL | 0.1448 mL | 0.2895 mL | 0.7238 mL | |
| 60 mM | 0.0241 mL | 0.1206 mL | 0.2413 mL | 0.6032 mL | |
| 80 mM | 0.0181 mL | 0.0905 mL | 0.1810 mL | 0.4524 mL | |
| 100 mM | 0.0145 mL | 0.0724 mL | 0.1448 mL | 0.3619 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
TCO-PEG8-NHS ester Related Classifications
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