Propargyl-PEG1-NH2
Based on 1 Customer Validation
Propargyl-PEG1-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 122116-12-5
- Formula: C5H9NO
- Molecular Weight:99.13
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 122116-12-5
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Appearance Liquid (Density: 0.945 g/cm3)
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Molecular Weight 99.13
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Formula C5H9NO
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Color Colorless to light yellow
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SMILES
C#CCOCCN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (1008.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (629 KB)
- English - EN (629 KB)
- Français - FR (629 KB)
- Deutsch - DE (629 KB)
- Norwegian - NO (629 KB)
- Español - ES (629 KB)
- Swedish - SV (629 KB)
- Italian - IT (629 KB)
- Korean - KR (629 KB)
- Portuguese - PT (629 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 10.0878 mL | 50.4388 mL | 100.8776 mL | 252.1941 mL |
| 5 mM | 2.0176 mL | 10.0878 mL | 20.1755 mL | 50.4388 mL | |
| 10 mM | 1.0088 mL | 5.0439 mL | 10.0878 mL | 25.2194 mL | |
| 15 mM | 0.6725 mL | 3.3626 mL | 6.7252 mL | 16.8129 mL | |
| 20 mM | 0.5044 mL | 2.5219 mL | 5.0439 mL | 12.6097 mL | |
| 25 mM | 0.4035 mL | 2.0176 mL | 4.0351 mL | 10.0878 mL | |
| 30 mM | 0.3363 mL | 1.6813 mL | 3.3626 mL | 8.4065 mL | |
| 40 mM | 0.2522 mL | 1.2610 mL | 2.5219 mL | 6.3049 mL | |
| 50 mM | 0.2018 mL | 1.0088 mL | 2.0176 mL | 5.0439 mL | |
| 60 mM | 0.1681 mL | 0.8406 mL | 1.6813 mL | 4.2032 mL | |
| 80 mM | 0.1261 mL | 0.6305 mL | 1.2610 mL | 3.1524 mL | |
| 100 mM | 0.1009 mL | 0.5044 mL | 1.0088 mL | 2.5219 mL |
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