Propargyl-PEG1-NH2

Name: Propargyl-PEG1-NH2
Brand: MedChemExpress
SKU: HY-116069
Rating: 4.5 (1 reviews)

Cat. No.: HY-116069 Purity: 98.80%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Propargyl-PEG1-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG1-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG1-NH2 Chemical Structure

CAS No. : 122116-12-5

Size	Price	Stock	Quantity
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Propargyl-PEG1-NH2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs^[1]. Propargyl-PEG1-NH2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

99.13

Formula

C₅H₉NO

CAS No.

122116-12-5

Appearance

Liquid

Color

Colorless to light yellow

SMILES

C#CCOCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (1008.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	10.0878 mL	50.4388 mL	100.8776 mL
5 mM	2.0176 mL	10.0878 mL	20.1755 mL
10 mM	1.0088 mL	5.0439 mL	10.0878 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.80%

Select Batch:

Data Sheet (267 KB) SDS (630 KB)

COA (242 KB) HNMR (116 KB) GC (245 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	10.0878 mL	50.4388 mL	100.8776 mL	252.1941 mL
	5 mM	2.0176 mL	10.0878 mL	20.1755 mL	50.4388 mL
	10 mM	1.0088 mL	5.0439 mL	10.0878 mL	25.2194 mL
	15 mM	0.6725 mL	3.3626 mL	6.7252 mL	16.8129 mL
	20 mM	0.5044 mL	2.5219 mL	5.0439 mL	12.6097 mL
	25 mM	0.4035 mL	2.0176 mL	4.0351 mL	10.0878 mL
	30 mM	0.3363 mL	1.6813 mL	3.3626 mL	8.4065 mL
	40 mM	0.2522 mL	1.2610 mL	2.5219 mL	6.3049 mL
	50 mM	0.2018 mL	1.0088 mL	2.0176 mL	5.0439 mL
	60 mM	0.1681 mL	0.8406 mL	1.6813 mL	4.2032 mL
	80 mM	0.1261 mL	0.6305 mL	1.2610 mL	3.1524 mL
	100 mM	0.1009 mL	0.5044 mL	1.0088 mL	2.5219 mL