2. Signaling Pathways
  3. PROTAC
  4. Proteasome Cap Targeting Chimeras

Proteasome Cap Targeting Chimeras

CAP-TACs

Proteasome Cap Targeting Chimeras (CAP-TACs) are a class of small-molecule-based bifunctional recruiting molecules. These molecules are capable of recruiting a diverse range of target proteins (POIs)—including BRD4, PRMT5, and FKBP12—to specific subunits within the 19S regulatory cap region (e.g., the RPN13 or RPN1 subunits). This recruitment subsequently induces the degradation of these POIs via a mechanism that is proteasome-dependent but ubiquitin-independent.

Proteasome Cap Targeting Chimeras Related Products (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-181521
    RAPRMT5 2721998-42-9
    RAPRMT5 is a PRMT5 CAP-TAC (proteinase complex-targeted chimeric agent) degrader. RAPRMT5 can induce PRMT5 to undergo proteasome-dependent, ubiquitin-independent degradation. RAPRMT5 can be used in the research of various cancers.
    RAPRMT5
  • HY-181495
    RAJQ14 2375455-53-9
    RAJQ14 is a BRD4 PROTAC-like CAP-TAC (Proteasome Cap Targeting Chimeras) degrader. RAJQ14 binds to 19S proteasome cap subunits RPN1, RPN10, RPN13, and USP14 to recruit target proteins to the proteasome for ubiquitination-independent, proteasome-dependent degradation. RAJQ14 can be used for the research of cancer (Pink: BRD4 Ligand (HY-181496); Blue: Proteasome Ligand (HY-128978); Black: Linker).
    RAJQ14
  • HY-181498
    RAFKBP12 2375455-59-5
    RAFKBP12 is a FKBP12 CAP-TAC (proteinase complex cap-targeted chimera) degrader. RAFKBP12 demonstrates the feasibility of the CAP-TAC strategy, which enables proteasome-dependent degradation of FKBP12 that is independent of E3 ubiquitin ligases and protein ubiquitination.
    RAFKBP12