CD40

CD40 Related Products (41):

By Type:	Pan (25) Selective (12)
By Effects:	Inhibitors (38) Antagonist (1) Activator (1)

Cat. No.	Product Name	Effect	Purity

HY-110203

R-7050	Antagonist	99.26%
R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.

HY-118250

GSK2245035	Activator	99.84%
GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties.

HY-107390

AX-024	Inhibitor	99.29%
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM.

HY-133807

Benpyrine	Inhibitor	99.56%
Benpyrine is a highly specific and orally active TNF-α inhibitor with a K_D value of 82.1 μM.

HY-134471

TNF-α-IN-2	Inhibitor	98.12%
TNF-α-IN-2 is a potent and orally active inhibitor of tumor necrosis factor alpha (TNFα), with an IC₅₀ of 25 nM in the HTRF assay.

HY-P99167

Lucatumumab	Inhibitor
Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling.

HY-P99670

Iscalimab	Inhibitor
Iscalimab (CFZ-533) is a non-depleting IGg1 monoclonal antibody targeting CD40 (K_D: 0.3 nM).

HY-P99325

Toralizumab	Inhibitor
Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains.

HY-119307

Apratastat	Inhibitor	99.67%
Apratastat (TMI-005) is an orally active, non-selective and reversible TACE/MMPs inhibitor, can inhibit inhibit the release of TNF-α.

HY-P9953

Certolizumab pegol	Inhibitor	99.30%
Certolizumab pegol (Certolizumab) is a recombinant, polyethylene glycolylated, antigen-binding fragment of a humanized monoclonal antibody that selectively targets and neutralizes tumour necrosis factor-α (TNF-α).

HY-N1949

Homoplantaginin	Inhibitor	99.90%
Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia with antiinflammatory and antioxidant properties.

HY-107390A

AX-024 hydrochloride	Inhibitor	99.12%
AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM.

HY-147045

UCB-5307	Inhibitor
UCB-5307 is a potent TNF signaling inhibitor with a K_D of 9 nM for human TNFα.

HY-135674

SR-318	Inhibitor	98.87%
SR-318 is a potent and highly selective p38 MAPK inhibitor with IC₅₀s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively.

HY-133807A

(Rac)-Benpyrine	Inhibitor	99.30%
(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor.

HY-P99111

Golimumab	Inhibitor	99.68%
Golimumab (CNTO-148) is a potent human IgG1 TNFα antagonist monoclonal antibody.

HY-115620

AQX-016A	Inhibitor	98.00%
AQX-016A is an orally active and potent SHIP1 agonist.

HY-N7012

7,3',4'-Tri-O-methylluteolin	Inhibitor	99.28%
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines.

HY-W082785A

L6H21	Inhibitor
L6H21, a Chalcone (HY-121054) derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor.

HY-107352

Fosfenopril	Inhibitor
Fosfenopril (Fosinoprilat) is a potent angiotensin converting enzyme (ACE) inhibitor.

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