Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (10876):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N5134S4

5'-Guanylic acid-¹⁵N₅,d₁₂ dilithium
5'-Guanylic acid-¹⁵N₅,d₁₂ (5'-GMP-¹⁵N₅,d₁₂ dilithium; 5'-guanosine monophosphate-¹⁵N₅,d₁₂) dilithium is deuterium and ¹⁵N labeled 5'-Guanylic acid (HY-N5134). 5'-Guanylic acid (5'-GMP) is involved in several metabolic disorders, including the AICA-ribosiduria pathway, adenosine deaminase deficiency, adenine phosphoribosyltransferase deficiency (aprt), and the 2-hydroxyglutric aciduria pathway.

HY-144086S

22:0 Lyso-PC-d₄
22:0 Lyso-PC-d₄ is the deuterium labeled 22:0 Lyso-PC.

HY-W713900

MCPA-d₃
MCPA-d₃-1 is the deuterium labeled MCPA (HY-B0859). MCPA is an orally active phenoxyacetic acid herbicide. MCPA interferes with membrane integrity, energy metabolism (decreases ATP levels), and redox balance in plant cells. MCPA increases hepatic cytochrome P-450 levels and increases aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities. MCPA can be used to control broadleaf weeds.

HY-13017S4

Ivacaftor-¹³C₆
Ivacaftor-¹³C₆ (VX-770-¹³C₆) is ¹³C labeled Ivacaftor. Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC₅₀s of 100 nM and 25 nM, respectively.

HY-119683S1

Epoxiconazole-d₄
Epoxiconazole-d4 is the deuterium labeled Epoxiconazole (HY-119683). Epoxiconazole, a fungicide, is a demethylation inhibitor of the Ergosterol biosynthesis pathway. Epoxiconazole exhibits strong inhibitory effects on both carbendazim-resistant and phenamacril-resistant isolates, and can be used for controlling many crop diseases.

HY-W106110S

9-Bromo-10-(2-naphthyl)anthracene-d₁₅
9-Bromo-10-(2-naphthyl)anthracene-d₁₅ is the deuterium labeled 9-Bromo-10-(2-naphthyl)anthracene.

HY-107370S

Atomoxetine-d₇
Atomoxetine-d₇ (Tomoxetine-d₇) is deuterium labeled Atomoxetine. Atomoxetine (Tomoxetine) is a selective noradrenaline reuptake inhibitor with K_i values of 5, 77 and 1451 nM for norepinephrine (NE), serotonin (5-HT) and dopamine (DA) transporters, respectively. Atomoxetine (Tomoxetine) increases of DA_EX and NE_EX in the PFC and enhances catecholaminergic neurotransmission. Atomoxetine (Tomoxetine) is a potent Na⁺ channels (VGSCs) blocker. Atomoxetine (Tomoxetine) can be used for attention-deficit hyperactivity disorder (ADHD) research.

HY-B0109S

Dorzolamide-d₅
Dorzolamide-d₅ is the deuterium labeled Dorzolamide. Dorzolamide (L671152) is a potent carbonic anhydrase II inhibitor, with IC₅₀ values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity.

HY-19436S

Solabegron-d₈
Solabegron-d₈ (GW 427353-d₈) is deuterium labeled Solabegron. Solabegron (GW 427353) is a selective β₃-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β₃-AR, with an EC₅₀ value of 22 nM. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome.

HY-B1971S1

Deltamethrin-d₆
Deltamethrin-d₆ (Decamethrin-d₆) is deuterium labeled Deltamethrin. Deltamethrin (Decamethrin) is an orally active synthetic pyrethroid insecticide. Deltamethrin induces oxidative stress and results in inflammation and apoptosis via inhibiting Nrf2/HO-1 pathway. Deltamethrin has an anticancer effect by inducing apoptosis. Deltamethrin can be used extensively in pest control.

HY-B1449S12

Uridine-d₁₂
Uridine-d12 (β-Uridine-d12) is the deuterium labeled Uridine (HY-B1449). Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, aribofuranose) via a β-N1-glycosidic bond.

HY-146875S

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol-d₃₁ ammonium		≥99.0%
1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol-d₃₁ (ammonium) is deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoinositol (ammonium).

HY-W719074

Sulfisomidin-d₄
Sulfisomidin-d₄ (Sulfaisodimidine-d₄) is deuterium labeled Sulfisomidin. Sulfisomidin (Sulfaisodimidine) is an orally active short-acting sulfonamide antibacterial. Sulfisomidin can be used for the research of lower urinary tract infections.

HY-W779021

Adenosine-¹⁵N
Adenosine-¹⁵N (Adenine riboside-¹⁵N) is ¹⁵N labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-W007102S

4-Methoxy-N,N-dimethylaniline-d₂
4-Methoxy-N,N-dimethylaniline-d2 is the deuterium labeled 4-Methoxy-N,N-dimethylaniline (HY-W007102).

HY-W014423S1

L-Histidine-¹³C₆,¹⁵N₃,d₅ hydrochloride hydrate
L-Histidine-¹³C₆,¹⁵N₃,d₅ hydrochloride hydrate is the deuterium, ¹³C-, and 15-labeled L-Histidine hydrochloride hydrate (HY-W014423). L-Histidine hydrochloride hydrate is an endogenous metabolite. L-Histidine hydrochloride hydrate scavenges hydroxyl radicals and singlet oxygen, regulate the absorption of zinc, copper and iron, exhibits anti-inflammatory and antioxidant activities. L-Histidine hydrochloride hydrate is blood brain barrier penetrable.

HY-P60760S1

TPSLP{pT}PPTR-¹³C₆,¹⁵N₄ TFA
TPSLP{pT}PPTR-¹³C₆,¹⁵N₄ TFA is the ¹³C- and ¹⁵N-labeled TPSLP{pT}PPTR TFA. TPSLP{pT}PPTR TFA is a tau protein fragment phosphorylated in the central region.

HY-W654195

3-Hydroxyfluorene-d₉
3-Hydroxyfluorene-d₉ is deuterium labeled 3-Hydroxyfluorene.

HY-130239S

14(S)-HDHA-d₅
14(S)-HDHA-d₅ (14(S)-HDoHE-d₅) is deuterium labeled 14(S)-HDHA. 14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway.

HY-132523S

Menaquinone Epoxide-d₇
Menaquinone 4-d₇ 2,3-Epoxide is the deuterium labeled Menaquinone 4 2,3-Epoxide.

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