2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipase

Lipase

Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-Y1422P
    Lipase, Rhizopus oryzae
    Lipase, Rhizopus oryzae (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
    Lipase, Rhizopus oryzae
  • HY-N12294
    Ciwujianoside D2
    		Inhibitor
    Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside D2
  • HY-N12294
    Ciwujianoside D2
    		Activator
    Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside D2
  • HY-P991937
    SOL-116
    		Inhibitor
    SOL-116 is a humanized anti-BSSL antibody. SOL-116 blocks BSSL from binding to monocytes. SOL-116 reduces the severity of Pristane (HY-N7819)-induced arthritis in rats.
    SOL-116
  • HY-Y1422Q
    Lipase, Rhizopus niveus
    Lipase, Rhizopus niveus (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
    Lipase, Rhizopus niveus
  • HY-123862
    LAS195319
    		Inhibitor
    LAS195319 is an orally active and potent inhibitor against PI3Kδ with an IC50 value of 0.5 nM. LAS195319 is also a highly selective inhibitor against an extensive panel of proteins, lipid kinases and GPCRs. LAS195319 causes an inhibition of neutrophil and eosinophil infiltration. LAS195319 is promising for research of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
    LAS195319
  • HY-Y1422O
    Lipase, Thermus flavus
    Lipase, Thermus flavus (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
    Lipase, Thermus flavus
  • HY-Y1422N
    Lipase, Thermus thermophilus
    Lipase, Thermus thermophilus (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
    Lipase, Thermus thermophilus
  • HY-172535
    Lipid OA2 dihydrochloride
    Lipid OA2 dihydrochloride is an ionizable cationic lipid that can be used to prepare single-component lipid nanoparticles for siRNA delivery. Lipid OA2 dihydrochloride can effectively deliver SOCS1-siRNA to dendritic cells, silence the SOCS1 gene, and enhance their antigen-presenting ability and pro-inflammatory factor secretion capacity.
    Lipid OA2 dihydrochloride
  • HY-N11721
    5-Hydroxyaloin A
    5-Hydroxyaloin A is a polyphenolic antioxidant agent. 5-Hydroxyaloin A forms hydrogen bonding interactions at lipase’s active site and SOD’s active site with low binding energy. 5-Hydroxyaloin A inhibits microsomal lipid peroxidation induced by ferrous-cysteine, reducing malondialdehyde production. 5-Hydroxyaloin A can be used for the research of obesity.
    5-Hydroxyaloin A
  • HY-N12296
    Ciwujianoside C4
    		Activator
    Ciwujianoside C4, a saponin compound, can enhance pancreatic lipase activity in vitro.
    Ciwujianoside C4
  • HY-N8989
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate
    		Inhibitor
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate, isolated from the ethanol extract of Atractylodes lancea rhizome, displays significant lipase inhibition with an IC50 value of 23.9 µg/mL. Antiobesity Effect.
    (1,5E,11E)-Tridecatriene-7,9-diyne-3,4-diacetate
  • HY-157534
    Pancreatic lipase-IN-2
    Pancreatic lipase-IN-2 (compound 7r) is a potent inhibitor of pancreatic lipase (PL), with the IC50 value of 2.67 μM, that has anti-obesity effect.
    Pancreatic lipase-IN-2
  • HY-N18267
    (3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate
    		Inhibitor
    (3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate is a polyacetylene found in Atractylodes lancea rhizome. (3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate inhibits human pancreatic lipase inhibitor with an IC50 of 39.91 μM. (3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate can be used for the research of obesity.
    (3Z,5E,11E)-3,5,11-Tridecatriene-7,9-diyn-1-ol, 1-acetate
  • HY-N17567
    Morusalnol A
    		Inhibitor
    Morusalnol A is a arylbenzofuran derivative found in the root bark of Morus alba. Morusalnol A is a pancreatic lipase inhibitor with a porcine pancreatic lipase IC50 of 0.71 μM. Morusalnol A inhibits pancreatic lipase activity. Morusalnol A can be used for the research of obesity.
    Morusalnol A
  • HY-126564
    Ebelactone A
    		Inhibitor 98.28%
    Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC50s of 56, 3, 8 and 7.5 μM, respectively. Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis.
    Ebelactone A
  • HY-N18145
    (3Z,5E,11E)-3,5,11-Tri-decatriene-7,9-diyne-1,2-diacetate
    		Inhibitor
    (3Z,5E,11E)-3,5,11-Tri-decatriene-7,9-diyne-1,2-diacetate is a human pancreatic lipase inhibitor, with an IC50 of 77.97 μM against human pancreatic lipase. (3Z,5E,11E)-3,5,11-Tri-decatriene-7,9-diyne-1,2-diacetate is applicable to the research of obesity.
    (3Z,5E,11E)-3,5,11-Tri-decatriene-7,9-diyne-1,2-diacetate
  • HY-Y1422M
    Lipase,wheat germ
    Lipase,wheat germ (EC 3.1.1.3) is an enzyme that catalyses the following chemical reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.
    Lipase,wheat germ
  • HY-N16617
    Platycodin V
    		Inhibitor
    Platycodin V is a triterpenoid saponin. Platycodin V has a relatively weak inhibitory effect on pancreatic lipase.
    Platycodin V
  • HY-N17996
    3'-O-Methy isosaponarin
    		Inhibitor
    3'-O-Methylisosaponarin is a spsoscoparin glycoside found in the leaves of C. sativus cultivar Chinese Yellow. 3'-O-Methylisosaponarin shows weak anti-lipase activity. 3'-O-Methylisosaponarin can be used for the research of disturbances of lipid metabolism.
    3'-O-Methy isosaponarin
Cat. No. Product Name / Synonyms Application Reactivity