2. Metabolic Enzyme/Protease
  3. Lipase
  4. SOL-116

SOL-116 is a humanized anti-BSSL antibody. SOL-116 blocks BSSL from binding to monocytes. SOL-116 reduces the severity of Pristane (HY-N7819)-induced arthritis in rats.

For research use only. We do not sell to patients.

SOL-116

SOL-116 Chemical Structure

Size Stock
1 mg   Get quote  
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

SOL-116 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SOL-116 is a humanized anti-BSSL antibody. SOL-116 blocks BSSL from binding to monocytes. SOL-116 reduces the severity of Pristane (HY-N7819)-induced arthritis in rats[1].

Species Reactivity

Human
IC50 & Target[1]

Bile salt-stimulated lipase (BSSL)

 

In Vitro

SOL-116 binds to human, mouse, and rat BSSL with approximately 80-fold lower affinity to rodent BSSL than to human BSSL due to a single amino acid epitope deviation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SOL-116 Related Antibodies
In Vivo

SOL-116 (10-90 mg/kg; s.c.; on day 5, 10 and 15 after disease induction) reduces disease severity in DA rats with Pristane (HY-N7819)-induced arthritis (with a dose response across 10, 30, and 90 mg/kg doses)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DA rats (pristane-induced arthritis)[1]
Dosage: 10, 30, 90 mg/kg
Administration: s.c.; on day 5, 10 and 15 after disease induction
Result: Significantly mitigated disease severity at 90 mg/kg; showed decreases in disease severity at 10 mg/kg and 30 mg/kg (dose response, not statistically significant); correlated plasma concentration at day 19 significantly to the arthritis score
Clinical Trial
Gene ID

682  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SOL-116 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SOL-116SOL116SOL 116LipaseDA ratsRAchronic inflammatory joint diseasesBSSLCD14+ monocyte migrationmonocytesPsAJIApristane induced arthritis rat modelsinflammation/immunology researchInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SOL-116
Cat. No.:
HY-P991937
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.