1. Membrane Transporter/Ion Channel
  2. Proton Pump

Tegoprazan 

Cat. No.: HY-17623
Handling Instructions

Tegoprazan, a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro.

For research use only. We do not sell to patients.

Tegoprazan Chemical Structure

Tegoprazan Chemical Structure

CAS No. : 942195-55-3

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Tegoprazan, a potassium-competitive acid blocker, is a potent, oral active and highly selective inhibitor of gastric H+/K+-ATPase that could control gastric acid secretion and motility, with IC50 values ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro[1].

IC50 & Target

IC50: 0.29-0.52 μM (H+/K+-ATPase)[1].

In Vitro

Tegoprazan inhibits porcine, canine, and human H+/K+-ATPase activity. Tegoprazan inhibits gastric H+/K+-ATPase in a potassium-competitive and reversible manner. Tegoprazan (3 μM) inhibits 86% of H+/K+-ATPase activity, whereas the inhibition is decreased to 34% after the dilution of Tegoprazan concentration to 0.15 μM[1].

In Vivo

Tegoprazan (1.0 mg/kg, p.o.) potently and completely inhibits histamine-induced gastric acid secretion in dogs. Tegoprazan (1.0-3.0 mg/kg, p.o.) reverses the pentagastrin-induced acidified gastric pH to the neutral range. Tegoprazan (3 mg/kg, p.o.) immediately evokes a gastric phase III contraction of the migrating motor complex in pentagastrin-treated dogs[1].

References
Molecular Weight

387.38

Formula

C₂₀H₁₉F₂N₃O₃

CAS No.

942195-55-3

SMILES

FC1=CC(F)=C2[[email protected]@H](OC3=CC(C(N(C)C)=O)=CC4=C3N=C(C)N4)CCOC2=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Tegoprazan
Cat. No.:
HY-17623
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Tegoprazan

Cat. No.: HY-17623