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Tyloxapol (Synonyms: Triton WR1339)

Cat. No.: HY-B1068
Handling Instructions

Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol (Triton WR1339) is used to induce hyperlipidemia in animals.

For research use only. We do not sell to patients.

Tyloxapol Chemical Structure

Tyloxapol Chemical Structure

CAS No. : 25301-02-4

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500 mg USD 55 In-stock
Estimated Time of Arrival: December 31
1 g USD 66 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol (Triton WR1339) is used to induce hyperlipidemia in animals[1][2].

In Vitro

Tyloxapol (100 μg/mL) triggers the detachment of HEK293 cells[2].
Tyloxapol induces nuclear fragmentation and the appearance of apoptotic nuclei[2].
Tyloxapol increases the risk of pulmonary haemorrhage, causes cytotoxicity in epithelial and red blood cells, and induces lysis of human Jurkat T-lymphoblasts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tyloxapol (Triton WR1339, 50 mg/kg) causes significant (P < 0.05) decreases in the activities of the AChE and MAO enzymes in rat plasma and brain[1].
Tyloxapol leads to significant (P < 0.05) reduction in the plasma urea, creatinine, and bilirubin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Twenty-one adult male Wistar rats, aged 11–12 weeks weighing 180-200 g[1].
Dosage: 50 mg/kg.
Administration: Injected intraperitoneally, BW, every other day.
Result: Caused a significant (P < 0.05) elevation in the levels of TBARS combined with an inhibition of the antioxidant enzymes (GPx, GST, CAT, SOD) in rat plasma, liver, and brain.
Induced DNA fragmentation and inhibited the activities of acetylcholinesterase and mono aminoxidase in the brain.
Molecular Weight

261.38 (monomer)

Formula

(C15H21O(C2H4O)m)n

CAS No.
SMILES

[H]OCCOC1=C(CC)C=C(C(CC(C)(C)C)(C)C)C=C1C.[6].[=].[<].[5].[8].[n].[m].[_].[=].[m].[n]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 120 mg/mL (Need ultrasonic)

Ethanol : 100 mg/mL (Need ultrasonic)

DMSO : ≥ 38 mg/mL

*"≥" means soluble, but saturation unknown.

In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (Infinity mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
References

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