1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Acetamiprid

Acetamiprid 

Cat. No.: HY-B0823 Purity: >98.0%
Handling Instructions

Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders.

For research use only. We do not sell to patients.

Acetamiprid Chemical Structure

Acetamiprid Chemical Structure

CAS No. : 135410-20-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 83 In-stock
Estimated Time of Arrival: December 31
100 mg USD 75 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders[1][2].

IC50 & Target

nAChR[1]

In Vivo

Acetamiprid decreases in body weight and mildly affected spermatogenesis. [1].
Acetamiprid decreases the expression of testosterone-metabolism genes, nAChR subunit genes, and proliferation-associated genes in mice[1].
Acetamiprid disrupts subsequent testosterone biosynthesis by decreasing the rate of conversion of cholesterol to testosterone and by preventing cholesterol from entering the mitochondria within the Leydig cells. These effects caused reproductive damage to the rats[2].

Animal Model: Male Sprague Dawley (SD) rats[2]
Dosage: 10 mg/kg, 30 mg/kg
Administration: Oral gavage; daily; for 35 days
Result: Inhibited testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells.
Molecular Weight

222.67

Formula

C₁₀H₁₁ClN₄

CAS No.

135410-20-7

SMILES

C/C(N(CC1=CC=C(Cl)N=C1)C)=N\C#N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (449.10 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4910 mL 22.4548 mL 44.9095 mL
5 mM 0.8982 mL 4.4910 mL 8.9819 mL
10 mM 0.4491 mL 2.2455 mL 4.4910 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.23 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AcetamipridnAChRNicotinic acetylcholine receptorsNeonicotinoidinsecticidereproductivespermatogenesisInhibitorinhibitorinhibit

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Acetamiprid
Cat. No.:
HY-B0823
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