2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Acetamiprid

Acetamiprid 

Cat. No.: HY-B0823 Purity: 99.88%
COA Handling Instructions

Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders.

For research use only. We do not sell to patients.

Acetamiprid Chemical Structure

Acetamiprid Chemical Structure

CAS No. : 135410-20-7

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Solution
10 mM * 1 mL in DMSO USD 83 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 83 In-stock
Solid
100 mg USD 75 In-stock
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Based on 1 publication(s) in Google Scholar

Acetamiprid Related Antibodies

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Description

Acetamiprid is a neonicotinoid insecticide used worldwide. Acetamiprid is a nicotinic acetylcholine receptor (nAChR) agonist, and is shown to be associated with neuromuscular and reproductive disorders[1][2].

IC50 & Target

nAChR[1]
In Vivo

Acetamiprid decreases in body weight and mildly affected spermatogenesis. [1].
Acetamiprid decreases the expression of testosterone-metabolism genes, nAChR subunit genes, and proliferation-associated genes in mice[1].
Acetamiprid disrupts subsequent testosterone biosynthesis by decreasing the rate of conversion of cholesterol to testosterone and by preventing cholesterol from entering the mitochondria within the Leydig cells. These effects caused reproductive damage to the rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley (SD) rats[2]
Dosage: 10 mg/kg, 30 mg/kg
Administration: Oral gavage; daily; for 35 days
Result: Inhibited testosterone synthesis by affecting the mitochondrial function and cytoplasmic adenosine triphosphate production in rat Leydig cells.
Molecular Weight

222.67

Appearance

Solid

Formula

C10H11ClN4
CAS No.
SMILES

C/C(N(CC1=CC=C(Cl)N=C1)C)=N\C#N.[(E)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (449.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4910 mL 22.4548 mL 44.9095 mL
5 mM 0.8982 mL 4.4910 mL 8.9819 mL
10 mM 0.4491 mL 2.2455 mL 4.4910 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.23 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.23 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.88%

COA (244 KB) HNMR (246 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References
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Acetamiprid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Acetamiprid135410-20-7nAChRNicotinic acetylcholine receptorsNeonicotinoidinsecticidereproductivespermatogenesisInhibitorinhibitorinhibit

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