2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Alfuzosin hydrochloride

Alfuzosin hydrochloride  (Synonyms: SL 77499-10)

Cat. No.: HY-B0192A Purity: 99.82%
COA Handling Instructions

Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH).

For research use only. We do not sell to patients.

Alfuzosin hydrochloride Chemical Structure

Alfuzosin hydrochloride Chemical Structure

CAS No. : 81403-68-1

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10 mM * 1 mL in DMSO USD 53 In-stock
Solid + Solvent
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ready for reconstitution
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10 mg USD 79 In-stock
50 mg USD 217 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Alfuzosin hydrochloride:

Alfuzosin hydrochloride Related Antibodies

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1 Publications Citing Use of MCE Alfuzosin hydrochloride

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Description

Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH)[1][2].

In Vivo

Alfuzosin hydrochloride (10 mg/kg, p.o.; single) potently antagonizes phenylephrine-induced increases in urethral and arterial pressures up to 6 hours post dosing[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (250-450 g)[1].
Dosage: 10 mg/kg
Administration: Oral administration; single.
Result: Increased prostatic concentrations to 4.1-8.6 times higher than plasma concentration.
Clinical Trial
Molecular Weight

425.91

Appearance

Solid

Formula

C19H28ClN5O4
CAS No.
SMILES

O=C(C1OCCC1)NCCCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (117.40 mM; Need ultrasonic)

DMSO : 25 mg/mL (58.70 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3479 mL 11.7396 mL 23.4791 mL
5 mM 0.4696 mL 2.3479 mL 4.6958 mL
10 mM 0.2348 mL 1.1740 mL 2.3479 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.82%

COA (249 KB) HNMR (284 KB) LCMS (267 KB)

Handling Instructions (2659 KB)
References
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Alfuzosin hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Alfuzosin81403-68-1SL 77499-10Adrenergic ReceptorBeta ReceptorBPHprostaticurinationbladder neckInhibitorinhibitorinhibit

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