2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. Anticancer agent 207

Anticancer agent 207 (compound 10b) is a potent anticancer agent. Anticancer agent 207 bounds to the NRAS rG4 with a KD value of 2.31 µM. Anticancer agent 207 shows cytotoxicity and decreases the expression of NRAS protein. Anticancer agent 207 shows antitumor activity.

For research use only. We do not sell to patients.

Anticancer agent 207 Chemical Structure

Anticancer agent 207 Chemical Structure

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Anticancer agent 207 Related Antibodies

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Description

Anticancer agent 207 (compound 10b) is a potent anticancer agent. Anticancer agent 207 bounds to the NRAS rG4 with a KD value of 2.31 µM. Anticancer agent 207 shows cytotoxicity and decreases the expression of NRAS protein. Anticancer agent 207 shows antitumor activity[1].

IC50 & Target[1]

NRAS rG4

2.31 μM (Kd)

In Vitro

Anticancer agent 207 (48 h) shows cytotoxicity for NRAS-mutant melanoma SK-MEL-2 with an IC50 value of 2.0 µM[1].
Anticancer agent 207 (0, 0.5, 1.0 µM; 72 h) decreases the expression of NRAS protein[1].
Anticancer agent 207 (0, 0.13, 0.25 µM; 10 days) inhibits the colony formation of SK-MEL-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 207 Related Antibodies

Western Blot Analysis[1]

Cell Line: SK-MEL-2 cells
Concentration: 0, 0.5, 1.0 µM
Incubation Time: 72 h
Result: Decreased the expression of NRAS protein in a dose-dependent manner.

Cell Proliferation Assay[1]

Cell Line: MCF-7, HepG2, HL60, A375 cells
Concentration: 0-100 µM
Incubation Time: 48 h
Result: Showed cytotoxicity with IC50s of 4.1, 1.5, 2.7, 4.5 µM for MCF-7, HepG2, HL60, A375 cells, respectively.
In Vivo

Anticancer agent 207 (1 mg/kg; i.p.; every day for 21 days) inhibits tumor growth in volume and weight in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male BALB/C nude mice (SK-MEL-2 xenograft mouse model)[1]
Dosage: 1 mg/kg
Administration: I.p.; every day for 21 days
Result: Suppressed tumor growth in volume and weight in the xenograft mouse model time-dependently.
Molecular Weight

494.64

Formula

C29H39FN4O2
SMILES

CCCCN(CCCOC1=CC=C2N=C3C4=C(OC3=C(C2=C1)NCCCN)C=CC(F)=C4)CCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 207 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 207Anticancer agent207Anticancer agent-207RasmelanomacytotoxicitySK-MEL-2 cellsantitumorNRAS rG4Inhibitorinhibitorinhibit

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